{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:58:21Z","timestamp":1772999901768,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertensive heart disease (HHD) remains a significant global health issue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analysed the global, regional, and national burden of HHD from 1990 to 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2021, the global prevalence, deaths, and disability\u2010adjusted life years (DALYs) associated with HHD were 12.5 million, 1.3 million and 25.5 million, respectively, exhibiting age\u2010standardized percentage changes of 18.2%, \u221222.0% and \u221225.8% compared to 1990. Jordan (341.9), Bulgaria (103.4) and Bulgaria (1739.3) had the highest age\u2010standardized prevalence, death and DALY rates, respectively, while Belarus recorded the lowest rates. DALYs reached their zenith in the 70\u201374 age range, but age\u2010standardized DALY rates were rising in the oldest age group (\u226595). A negative correlation was observed between the sociodemographic index and DALY rates. The key risk factors identified were high systolic blood pressure (100%), high BMI (49.3%) and insufficient fruit intake (37.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although case numbers have increased, age\u2010standardised death and DALY rates have declined since 1990. Targeted prevention strategies should prioritise blood pressure control, weight management and dietary measures to mitigate the burden of HHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70104","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:12Z","timestamp":1753877052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Burden of hypertensive heart disease and its attributable risk factors in 204 countries and territories, 1990\u20132021: Results from the global burden of disease study 2021"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9067-7650","authenticated-orcid":false,"given":"Jinhang","family":"Che","sequence":"first","affiliation":[{"name":"Department of Electrocardiographic Diagnosis The Fourth People's Hospital of Chengdu  Chengdu 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