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These patients are at increased risk of progressing to severe\u2013critical or prolonged COVID\u201019. Prompt treatment with antivirals has proven effective in preventing disease progression and is recommended by current guidelines. We discuss here the position of remdesivir in the management of onco\u2010hematologic patients infected with SARS\u2010CoV\u20102 and strategies for its use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Narrative review of current evidence regarding remdesivir in the treatment of COVID\u201019 in patients with hematologic malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with non\u2010severe COVID\u201019 should receive remdesivir as soon as possible after diagnosis, and within 7\u2009days from symptom onset. A 3\u2010day treatment duration is recommended. In patients at high risk of developing severe COVID\u201019 \u2013 patients with B\u2010cell depletion and recipients of allogeneic HSCT or CAR T cell therapy or bispecific antibodies \u2013 treatment may be prolonged and\/or combined with other COVID\u201019 therapeutics. Patients with severe COVID\u201019 requiring supplemental oxygen should receive remdesivir as soon as possible, preferentially for 10\u2009days. In those at high risk of progressing to critical COVID\u201019, combination of remdesivir with other COVID\u201019 therapeutics can be considered. In case of relapse or persisting symptoms, remdesivir treatment can be prolonged and\/or repeated or combined with other COVID\u201019 therapeutics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Evidence from clinical trials and real\u2010world studies shows that remdesivir is a valid option for the treatment of SARS\u2010CoV\u20102\u2010infected onco\u2010hematologic patients, across a wide spectrum of COVID\u201019 severity. The drawback of remdesivir\u2014intravenous administration mode\u2014is counterbalanced by good tolerability, negligible drug\u2013drug interactions and a high barrier to virus resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70108","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:30:39Z","timestamp":1755865839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of remdesivir for the treatment of COVID\u201019 in patients with hematologic malignancy\u2014A narrative review and expert opinion"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-4602","authenticated-orcid":false,"given":"Malgorzata","family":"Mikulska","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Della Salute (DISSAL) Universit\u00e0 di Genova  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Della Salute (DISSAL) Universit\u00e0 di Genova  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Busca","sequence":"additional","affiliation":[{"name":"SS Trapianto Allogenico Cellule Staminali AOU Citt\u00e0 Della Salute e Della Scienza  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Cento","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"},{"name":"Microbiology and Virology Unit IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddalena","family":"Giannella","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit IRCSS AOU di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Bartoletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"},{"name":"Infectious Diseases Unit IRCSS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100747"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_390778"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1207225"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01578-1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01938-5"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012251"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.09.002"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005616"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3086"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01920-1"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116846"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2118542"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116044"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2214302"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16040546"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105252"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2207519"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11101533"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108147"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-023-00900-3"},{"key":"e_1_2_13_22_1","unstructured":"EMA Summary of product characteristics. 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