{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:31Z","timestamp":1787014111687,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Age\u2010related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We analysed data from 408 CS\u2010TTS patients in the RETAKO registry. Patients were stratified into three age groups: \u226450\u2009years (9%), 51\u201374\u2009years (48%), and \u226575\u2009years (43%). In the youngest group, compared to the middle\u2010aged and the oldest groups, patients were more likely to be male (35% vs. 16% and 14%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01), have a physical trigger (65% vs. 43% and 49%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.04), exhibit atypical echocardiographic patterns (27% vs. 11% and 11%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02), and experienced a higher incidence of ventricular arrhythmias (24% vs. 8% and 7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01). In\u2010hospital mortality rates were 5% in younger patients, 12% in middle\u2010aged patients, and 15% in older patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.15). Older age independently predicted both in\u2010hospital mortality (OR 2.33, 95% CI 1.05\u20135.17; reference: middle\u2010aged) and 5\u2010year mortality (HR 3.69, 95% CI 1.77\u20137.67), regardless of shock severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In CS\u2010TTS, younger patients exhibit distinct clinical features but have better outcomes. Older age is associated with higher in\u2010hospital and long\u2010term mortality, regardless of comorbidities and shock severity. These findings underscore the need for age\u2010specific management strategies and further research into the mechanisms underlying age\u2010related differences in CS\u2010TTS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70119","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T12:40:31Z","timestamp":1756989631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010related differences in cardiogenic shock secondary to Takotsubo syndrome"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-4342","authenticated-orcid":false,"given":"Marco","family":"Tomasino","sequence":"first","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"},{"name":"Department of Cardiology Hospital Universitari Vall d'Hebron  Barcelona Spain"},{"name":"Vall d'Hebron Institut de Recerca (VHIR)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Vazirani","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Salamanca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010IP)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Raposeiras\u2010Roubin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital \u00c1lvaro Cunqueiro  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Fern\u00e1ndez\u2010Cord\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Valladolid  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Corb\u00ed\u2010Pascual","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario de Albacete  Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Vedia","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario de Torrej\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn C.","family":"Mart\u00edn\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complejo Asistencial Universitario de Salamanca  Salamanca Spain"},{"name":"CIBER\u2010CV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Blanco\u2010Ponce","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Arnau de Vilanova IRB LLeida  Lleida 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