{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:11:18Z","timestamp":1789726278742,"version":"4.0.1"},"reference-count":72,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 82070350"],"award-info":[{"award-number":["NSFC 82070350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with atrial fibrillation (AF) with end\u2010stage renal failure on renal replacement therapy are at high risk of stroke and bleeding, but the optimal oral anticoagulation (OAC) strategy is uncertain. To investigate the most effective OAC therapy for patients with AF on long\u2010term dialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, EMBASE and Web of Science databases were systematically searched from inception to 9 October 2024 to identify relevant studies on OAC strategy for patients with AF on long\u2010term dialysis. The effectiveness outcomes were ischaemic stroke and\/or systemic thromboembolism, all\u2010cause mortality and the safety endpoint was major bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The present study encompassed a comprehensive analysis of 33 studies involving a total of 137,574 patients with AF on long\u2010term dialysis. All OACs, including warfarin (hazard ratio [HR], .963; 95% confidence interval [CI], .841\u20131.104), did not show a statistically significant decrease in the risk of ischaemic stroke and\/or systemic thromboembolism compared to no anticoagulant therapy. Only apixaban 5\u2009mg twice daily was associated with a lower risk of all\u2010cause mortality compared to non\u2010OAC use (HR, .671; 95% CI, .490\u2013.919). Dabigatran (HR, 2.140; 95% CI, 1.734\u20132.642) and phenprocoumon (HR, 2.419; 95% CI, 1.241\u20134.713) were associated with a significantly higher risk of major bleeding than non\u2010OAC use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>All OACs were not associated with a reduced risk of ischaemic stroke and\/or systemic thromboembolism in patients with AF on long\u2010term dialysis. Only apixaban 5\u2009mg twice daily was associated with a decrease in all\u2010cause mortality when compared with non\u2010OAC use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70120","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T12:06:36Z","timestamp":1757333196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oral anticoagulant therapy for patients with atrial fibrillation on long\u2010term dialysis: A network meta\u2010analysis of 137,574 patients"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9902-6069","authenticated-orcid":false,"given":"Yao","family":"Du","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"},{"name":"The First People's Hospital of Jiujiang  Jiujiang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. 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