{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:30Z","timestamp":1787014110306,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma cell disorder with potential progression to multiple myeloma (MM). Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) have demonstrated potential anti\u2010neoplastic properties. This study evaluated the association between GLP\u20101 RA use and clinical outcomes in individuals with MGUS and concurrent DM, overweight or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted using the TriNetX global health research network. Adults with MGUS and either DM or overweight\/obesity were identified. Propensity score matching (1:1) was performed, resulting in two balanced cohorts. The primary outcome was progression\u2010free survival (PFS). Secondary outcomes included overall survival (OS), time to progression to multiple myeloma (MM) and major cardiovascular events, including myocardial infarction (MI), ischemic stroke, ischemic heart disease and heart failure (HF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 30,034 matched patients, 823 patients in the GLP\u20101 RA group and 2317 in the control group progressed to symptomatic MM or died. GLP\u20101 RA use was associated with significantly improved PFS [HR (95% CI): .63 (.58\u2013.68)] and OS [HR (95% CI): .61 (.56\u2013.66)]. A reduced risk of progression to symptomatic MM was also observed [HR (95% CI): .82 (.69\u2013.98)]. GLP\u20101 RA users had lower cumulative incidence of MI, HF, ischemic heart disease, and stroke; however, these differences were not confirmed in time\u2010to\u2010event analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 RA therapy was associated with significantly improved PFS and OS in MGUS patients with metabolic comorbidities. While fewer cardiovascular events were observed, these findings were not statistically confirmed over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70140","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:15:02Z","timestamp":1761131702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["GLP\u20101 receptor agonists in patients with MGUS: A real\u2010world propensity\u2010matched study"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5897-472X","authenticated-orcid":false,"given":"Anastasios","family":"Tentolouris","sequence":"first","affiliation":[{"name":"First Department of Propaedeutic Internal Medicine and Diabetes Center School of Medicine, National and Kapodistrian University of Athens, Laiko General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Ntanasis\u2010Stathopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Terpos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Kastritis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto Ruiz","family":"Duque","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios\u2010Athanasios","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital  Athens Greece"},{"name":"Department of Medicine Korea University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gavriatopoulou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Briasoulis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital  Athens Greece"},{"name":"Division of Cardiovascular Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0337"},{"key":"e_1_2_10_3_1","unstructured":"Global Cancer Obervatory.https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/35\u2010multiple\u2010myelomafact\u2010sheet.pdf. 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