{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:33:01Z","timestamp":1783110781263,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Late adverse events after percutaneous coronary intervention continue to occur beyond the first year with last\u2010generation drug\u2010eluting stents (DES). The coronary bioadaptor marks a new approach with an uncaging beginning at approximately 6\u2009months after implantation. We conducted a pairwise meta\u2010analysis of bioadaptor versus DES in randomised trials with complementary single\u2010arm 6\u201312 and 6\u201324 landmark analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The systematic review and meta\u2010analysis was conducted according to PRISMA 2020 Guidelines. PubMed, Embase, CENTRAL and Google Scholar were searched for studies reporting clinical outcomes after bioadaptor implantation. The primary outcome was target\u2010lesion failure (TLF), a composite of cardiac death, target\u2010vessel myocardial infarction and target\u2010lesion revascularisation at 1\u2009year. Secondary outcomes were TLF and individual components at landmark intervals 6\u201312 and 6\u201324\u2009months. Single\u2010arm pooled event rates and pairwise comparisons were estimated using generalised linear mixed\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three randomised trials (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092892; 1448 bioadaptor, 1444 DES) were included in pairwise analyses. 1\u2010year TLF showed no significant difference between bioadaptor and DES (OR 0.81, 95% CI 0.51\u20131.31,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3943). Likewise, individual components of TLF and device thrombosis did not differ between groups. Ten studies (1753 patients; 1900 lesions) were included in single\u2010arm analyses. Landmark TLF was 0.57% (95% CI 0.07\u20134.29;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20094.6%) from 6 to 12\u2009months and 2.01% (95% CI 0.81\u20134.92;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200974.2%) from 6 to 24\u2009months. Event rates for other endpoints were generally low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No significant differences in safety and efficacy outcomes were observed between bioadaptor and DES. Complementary single\u2010arm landmark analyses suggested low late event rates, but these findings should be interpreted as exploratory. Further randomised trials are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70217","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:25:26Z","timestamp":1778045126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Comprehensive Meta\u2010Analysis of Bioadaptor Versus Drug\u2010Eluting Stents in Randomised Trials With Exploratory Single\u2010Arm Landmark Analyses"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8823-802X","authenticated-orcid":false,"given":"Simon","family":"W\u00f6lbert","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Cardiology University Hospital Augsburg, University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2391-4226","authenticated-orcid":false,"given":"Stephanie","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology University Hospital Augsburg, University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7807-8772","authenticated-orcid":false,"given":"Andrea","family":"Patrignani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Humanitas Research Hospital IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-2658","authenticated-orcid":false,"given":"Mauro","family":"Chiarito","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Humanitas Research Hospital IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"von Scheidt","sequence":"additional","affiliation":[{"name":"Department of Cardiology German Heart Center, TUM University Hospital, Technical University Munich  Munich Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4959-7293","authenticated-orcid":false,"given":"Jan","family":"Torzewski","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Oberallg\u00e4u\u2010Kempten  Kempten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Raake","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology University Hospital Augsburg, University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-1482","authenticated-orcid":false,"given":"Dario","family":"Bongiovanni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology University Hospital Augsburg, University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7398.1080"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.058"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026041"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043773"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512417"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043467"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.05.003"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ\u2010D\u201020\u201000763"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010021\u201001308\u20108"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBISRIR\u2010D\u201019\u201000099"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029289"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000001232"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.03.026"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.03.028"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)02227\u2010X"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102304"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8876443"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.09.550"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2026.02.051"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.03.026"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.125.016191"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2025.01.426"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2022.09.009"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.12.005"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab280"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ\u2010D\u201022\u201001069"},{"key":"e_1_2_13_31_1","unstructured":"A. G.Biotronik \u201cBIOTRONIK\u2010Safety and Clinical Performance of the Drug Eluting Resorbable Coronary MAGnesium Scaffold System (DREAMS 3G) in the Treatment of Subjects With De Novo Lesions in Native Coronary Arteries: BIOMAG\u2010II: A Randomized Controlled Trial \u201d (2024) ClinicalTrials.gov https:\/\/clinicaltrials.gov\/study\/NCT05540223."},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.4101"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.70217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eci.70217","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.70217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:02:01Z","timestamp":1779433321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.70217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/eci.70217"],"URL":"https:\/\/doi.org\/10.1111\/eci.70217","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70217"}}