{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:12:21Z","timestamp":1784967141914,"version":"3.55.0"},"reference-count":79,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007480","name":"Universidad de Castilla-La Mancha","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality, which is mediated by arterial stiffness. Pulse wave velocity (PWV), as measured by the aortic (aPWV), brachial\u2010ankle (baPWV) and carotid\u2010radial (crPWV) indices or estimated by equations (ePWV), could be a powerful predictor of clinical events and mortality in this population. This study aimed to analyse the association between PWV and all\u2010cause mortality, cardiovascular mortality, and cardiovascular disease (CVD) risk in populations with CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted in PubMed, Scopus, and Web of Science from inception to January 2026. Observational studies estimating the association between PWV, categorically or by an increase of 1\u2009m\/s, and the outcomes of interest were included. Random\u2010effects meta\u2010analyses were performed, considering the type of PWV studied. The results are presented as hazard ratios (HR) and their 95% confidence intervals (95% CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010eight studies were included in the systematic review, and 22 in the meta\u2010analyses. Considering a 1\u2009m\/s increase in aPWV, HRs of 1.16 (95% CI: 1.06, 1.28), 1.36 (95% CI: 1.15, 1.61), and 1.20 (95% CI: 1.02, 1.41) were found for all\u2010cause mortality, cardiovascular mortality, and CVD risk, respectively. The remaining associations for aPWV, baPWV, and ePWV were categorical and tended to be higher.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased PWV was associated with an increased risk of mortality and CVD. However, given the low quality of the current evidence base, these findings should be interpreted with caution and more rigorous studies are needed to confirm their usefulness in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70222","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:45:22Z","timestamp":1778683522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pulse Wave Velocity, Mortality and Cardiovascular Disease in Chronic Kidney Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-8752","authenticated-orcid":false,"given":"Carlos","family":"Pascual\u2010Morena","sequence":"first","affiliation":[{"name":"Health and Social Research Center University of Castilla\u2014La Mancha  Cuenca Spain"},{"name":"Faculty of Nursing University of 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