{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:48:09Z","timestamp":1782283689183,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is the most common arrhythmia in the elderly, and is associated with an increased risk of cardiovascular events (CVE). Hypoalbuminemia is an independent predictor of all\u2010cause and cardiovascular mortality in general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this work is to evaluate the possible predictive value of serum albumin (SA) on MACE occurrence, in a cohort of elderly patients with non\u2010valvular AF and several comorbidities for long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>1057 elderly with non\u2010valvular AF were enrolled (75.92\u2009\u00b1\u20096.1years; 295 on VKAs and 762 on DOACs) and stratified according to median value of SA, 532 patients with SA \u2264\u20093.6\u2009g\/dL and 525 patients with SA &gt;\u20093.6\u2009g\/dL. MACE (non\u2010fatal ischemic stroke, non\u2010fatal myocardial infarction and cardiovascular death), and non\u2010cardiovascular mortality occurrence were evaluated during a median follow\u2010up of 5.5\u2009years (IQR 2.1\u20137.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the whole observational study, patients with SA \u2264\u20093.6\u2009g\/dL are associated with an increased risk of MACEs by 59%. In addition, 10\u2010year ageing are associated with an increased risk of MACE; in contrast, a MNA score &gt;\u200924 pt and therapy with DOACs are associated with a reduced risk of MACE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elderly patients with non\u2010valvular AF with SA \u2264\u20093.6\u2009g\/dL show a higher risk of MACE and non\u2010cardiovascular mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70237","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:58:03Z","timestamp":1781596683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Role of Serum Albumin Levels in Elderly Patients With Non\u2010Valvular Atrial Fibrillation"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-9715","authenticated-orcid":false,"given":"Giuseppe","family":"Armentaro","sequence":"first","affiliation":[{"name":"Geriatrics Division \u201cRenato Dulbecco\u201d University Hospital of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Crudo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University Magna Gr\u00e6cia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Menichelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Daidone","sequence":"additional","affiliation":[{"name":"Internal Medicine and Stroke Care Ward, 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