{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:00:42Z","timestamp":1784808042876,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sex\u2010specific differences regarding the prognostic impact of permanent pacemaker (PM) implantation after transcatheter aortic valve implantation (TAVI) remain largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate sex\u2010specific associations between pre\u2010existing and new post\u2010procedural PM implantation and short\u2010 and long\u2010term mortality after TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This post hoc analysis of a prospective registry included consecutive patients who underwent TAVI between 2016 and 2020. Patients were stratified by sex and assigned to three groups: no PM, pre\u2010existing PM (pre\u2010PM) and PM implantation within 30\u2009days of TAVI (post\u2010PM). The primary endpoint was 5\u2010year all\u2010cause mortality; the secondary endpoint was 30\u2010day mortality. Sex\u2010stratified multivariable proportional hazards models and Kaplan\u2013Meier analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1114 patients (81\u2009\u00b1\u20095\u2009years, 49.8% female), women more frequently had no PM (80.2% vs. 70.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and less often had a pre\u2010existing PM (7.0% vs. 14.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Post\u2010PM rates were similar between sexes (12.8% vs. 14.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.172). Thirty\u2010day survival differed by PM status only in women, with worse outcomes in the post\u2010PM group (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), whereas no difference was observed in men (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.542). Five\u2010year survival did not differ by PM status among women (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.572) but differed significantly among men (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with the lowest survival in men with pre\u2010PM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post\u2010procedural PM implantation was associated with higher 30\u2010day mortality in women, whereas pre\u2010existing PM predicted reduced 5\u2010year survival in men, supporting sex\u2010specific risk assessment before and after TAVI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70242","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:36:41Z","timestamp":1783057001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pacemaker Status and 5\u2010Year Mortality After\n                    <scp>TAVI<\/scp>\n                    : A Sex\u2010Specific Analysis"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9378-5000","authenticated-orcid":false,"given":"Cecilia","family":"Veraar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine 3 University Hospital St. P\u00f6lten \u2013 NOE LGA, Karl Landsteiner University  St. P\u00f6lten Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Lamm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3 University Hospital St. P\u00f6lten \u2013 NOE LGA, Karl Landsteiner University  St. P\u00f6lten Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Will","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3 University Hospital St. P\u00f6lten \u2013 NOE LGA, Karl Landsteiner University  St. P\u00f6lten Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hammerer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II Paracelsus Medical University of Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Granner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3 University Hospital St. P\u00f6lten \u2013 NOE LGA, Karl Landsteiner University  St. P\u00f6lten Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lion","family":"Merl","sequence":"additional","affiliation":[{"name":"Department of 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