{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:34:12Z","timestamp":1787589252039,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/14231\u20100"],"award-info":[{"award-number":["2021\/14231\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Heart rate variability (HRV) has remained a relatively finite and niche tool in cardiology despite decades of research supporting its physiological and clinical relevance. This limited adoption may resemble the early history of electrocardiography (ECG), which was initially regarded by many physicians as a laboratory instrument rather than a routine clinical tool. The delayed acceptance of ECG reflected technological limitations, cultural resistance and the need for clinicians to master unfamiliar concepts derived from physics and electrophysiology. HRV faces comparable barriers today. Although derived from ECG RR intervals, HRV requires interpretation of time\u2010domain, frequency\u2010domain, geometric and nonlinear indices that may appear mathematically complex and distant from conventional bedside reasoning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We argue that HRV should not be viewed as a replacement for ECG, but as an extension of ECG from electrical morphology to physiological dynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Lessons from ECG history were examined and compared with the current state of HRV adoption in clinical practice. The complementary diagnostic roles of ECG morphology and HRV analysis were considered, together with the potential contribution of wearable sensors, remote monitoring, artificial intelligence and large language models to facilitate HRV interpretation, education and clinical integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Whereas conventional ECG morphology identifies arrhythmias, conduction disturbances, ischemic alterations and overt electrical abnormalities, HRV provides insight into autonomic modulation, cardiovascular adaptability and systemic physiological regulation. The emergence of wearable sensors, remote monitoring, artificial intelligence and large language models creates an opportunity to overcome barriers that have limited HRV adoption. Artificial intelligence may serve as an educational and interpretive bridge, translating complex HRV metrics into clinically meaningful concepts while supporting medical training, artefact awareness, case\u2010based learning and workflow integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>HRV faces barriers comparable to those encountered during the early adoption of ECG, including technological limitations, educational challenges and resistance to incorporating unfamiliar physiological concepts into routine clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lessons from ECG history suggest that HRV adoption will depend not only on evidence but also on standardization, education, clinical interpretation and cultural acceptance within cardiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70249","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:41:19Z","timestamp":1786030879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Electrical Morphology to Physiological Dynamics: Lessons From\n                    <scp>ECG<\/scp>\n                    Adoption for the Clinical Integration of Heart Rate Variability"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-8446","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Puglisi","sequence":"first","affiliation":[{"name":"College of Medicine California Northstate University  Elk Grove California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpreet","family":"Sodhi","sequence":"additional","affiliation":[{"name":"College of Medicine California Northstate University  Elk Grove California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Minucci","family":"Carmargo","sequence":"additional","affiliation":[{"name":"Center for Technological Research Universidade de Mogi das Cruzes  Mogi das Cruzes S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-9873","authenticated-orcid":false,"given":"Daniel Gustavo","family":"Goroso","sequence":"additional","affiliation":[{"name":"Center for Technological Research Universidade de Mogi das Cruzes  Mogi das Cruzes S\u00e3o Paulo Brazil"},{"name":"Instituto de Sa\u00fade, Secretaria de Estado da Sa\u00fade de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00258"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542\u2010474X.2005.10101.x"},{"issue":"2","key":"e_1_2_12_5_1","first-page":"174","article-title":"Einthoven's String Galvanometer: The First Electrocardiograph","volume":"35","author":"Rivera\u2010Ruiz M.","year":"2008","journal-title":"Texas Heart Institute Journal"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/07341510601003081"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2013.07.024"},{"key":"e_1_2_12_8_1","first-page":"814","article-title":"Electronic Evaluation of the Fetal Heart Rate. 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