{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:50:37Z","timestamp":1791435037983,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Andes virus (ANDV) has recently emerged as a significant public health concern following a multi\u2010country outbreak aboard the MV Hondius cruise ship in April 2026, with 13 identified cases and three deaths among passengers and crew.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed available literature from PubMed and Google Scholar databases and searched international health agencies, including the World Health Organisation and national public health authorities, for current outbreak information and up\u2010to\u2010date epidemiological data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ANDV is a zoonotic orthohantavirus endemic in southern Chile and Argentina, with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Oligoryzomys longicaudatus<\/jats:italic>\n                      <\/jats:styled-content>\n                      as its principal reservoir. Approximately 300 cases of hantavirus cardiopulmonary syndrome occur annually in the Americas. The virus causes severe disease through endothelial dysfunction and vascular leakage, resulting in rapidly progressive pulmonary edema and shock. Human\u2010to\u2010human transmission is characteristic of ANDV and occurs through respiratory and salivary routes during prolonged close contact. Clinical presentation includes nonspecific prodromal symptoms followed by rapid cardiopulmonary deterioration. Diagnosis relies on serological assays and RT\u2010qPCR. Management is predominantly supportive, emphasising hemodynamic monitoring and early consideration of extracorporeal membrane oxygenation in severe cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite ANDV's severity and high mortality, its epidemic potential seems to be low. However, the recent outbreak underscores the importance of international surveillance coordination and rapid diagnostic capabilities for emerging zoonotic infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70255","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:57:38Z","timestamp":1788443858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Andes Virus: From Transmission Dynamics to Pandemic Potential"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0145-9740","authenticated-orcid":false,"given":"Matteo","family":"Bassetti","sequence":"first","affiliation":[{"name":"Department of Health Sciences (DISSAL) University of Genoa  Genoa Italy"},{"name":"Infectious Diseases Unit AOM \u2013 IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Sepulcri","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL) University of Genoa  Genoa Italy"},{"name":"Infectious Diseases Unit AOM \u2013 IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Maria","family":"Bucci","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-1759","authenticated-orcid":false,"given":"Daniele Roberto","family":"Giacobbe","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL) University of Genoa  Genoa Italy"},{"name":"Infectious Diseases Unit AOM \u2013 IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-3992","authenticated-orcid":false,"given":"Antonio","family":"Vena","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL) University of Genoa  Genoa Italy"},{"name":"Infectious Diseases Unit AOM \u2013 IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.s875"},{"key":"e_1_2_16_3_1","unstructured":"World Health Organization \u201cDisease Outbreak News. Hantavirus Cluster Linked to Cruise Ship Travel 2 July 2026 2026\u2010DON611 \u201d(2026)."},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00142-7"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00128-7"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01057-08"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2009040"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25446"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00396-21"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02992"},{"key":"e_1_2_16_11_1","doi-asserted-by":"crossref","unstructured":"R.Zust R.Ackermann\u2010Gaumann andN.Liechti \u201cPresence and Persistence of Andes Virus RNA in Human Semen \u201d(2023).","DOI":"10.3390\/v15112266"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25054"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13322"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149354"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-026-08497-0"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12839"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30129-0"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2024.154867"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/v17091241"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa654"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.201595"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2922"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009448"},{"key":"e_1_2_16_24_1","first-page":"75","volume-title":"Advances in Virus Research","author":"Pfeffermann K.","year":"2018"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12713"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-025-13474-6"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1233433"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc2412526"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-096313"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2021.198584"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPNFVWG46NUHED"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2024.100836"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2026.31.24.2600477"},{"key":"e_1_2_16_34_1","volume-title":"CDC Yellow Book","author":"Choi M. 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