{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:50:27Z","timestamp":1791435027849,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1HL092577"],"award-info":[{"award-number":["RO1HL092577"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1HL157635"],"award-info":[{"award-number":["RO1HL157635"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1HL177209"],"award-info":[{"award-number":["RO1HL177209"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K08HL171874"],"award-info":[{"award-number":["5K08HL171874"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["24CVD01"],"award-info":[{"award-number":["24CVD01"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with significant associated morbidity and mortality. The pathophysiology underlying AF is complex, and this has limited the development of effective therapies. ADAMs (a disintegrin and metalloproteinase) are transmembrane proteinases with diverse functions involving cell\u2013cell communication and extracellular matrix homeostasis. ADAM15 specifically has been implicated in AF pathogenesis in large\u2010scale genetic association studies. Given the importance of atrial remodelling in AF pathogenesis, we sought to ascertain the effect of ADAM15 deficiency in murine atrial biology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed extensive cardiac phenotyping in\n                      <jats:italic>Adam15<\/jats:italic>\n                      knockout (\n                      <jats:italic>Adam15<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ) mice; wildtype mice were used as controls. These studies included invasive electrophysiology, echocardiography, optical mapping and biochemical assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ADAM15 deficiency resulted in increased AF susceptibility without overt abnormalities in cardiac structure or function by echocardiography. These findings were associated with shortened atrial action potential duration, increased atrial fibrosis, increased TGF\u03b2 signalling, as well as reduced connexin expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Here, we provide evidence that ADAM15 deficiency is associated with increased AF susceptibility and atrial remodelling in mice. Further work will be needed to define the molecular mechanisms underlying these findings and determine their relevance to human AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70259","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:26:32Z","timestamp":1788848792000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Murine ADAM15 Deficiency Is Associated With Atrial Remodelling and Atrial Arrhythmia Susceptibility"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1996-522X","authenticated-orcid":false,"given":"Aneesh","family":"Bapat","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center, Mass General Brigham  Boston Massachusetts USA"},{"name":"Demoulas Center for Cardiac Arrhythmias, Mass General Brigham  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-6128","authenticated-orcid":false,"given":"Sebastian","family":"Clauss","sequence":"additional","affiliation":[{"name":"Department of Medicine I University Hospital Munich, Campus Gro\u00dfhadern, Ludwig\u2010Maximilians University Munich (LMU)  Munich Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance (MHA)  Munich Germany"},{"name":"Walter Brendel Centre of Experimental Medicine Ludwig\u2010Maximilians University Munich (LMU)  Munich Germany"},{"name":"Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5463-5576","authenticated-orcid":false,"given":"Ling","family":"Xiao","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Mass General Brigham  Boston Massachusetts USA"},{"name":"Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0701-6780","authenticated-orcid":false,"given":"Heather","family":"Jameson","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Mass General Brigham  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Retournard","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Mass General Brigham  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1362-9919","authenticated-orcid":false,"given":"Alan","family":"Hanley","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Mass General Brigham  Boston Massachusetts USA"},{"name":"Demoulas Center for Cardiac Arrhythmias, Mass General Brigham  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-0533","authenticated-orcid":false,"given":"Patrick T.","family":"Ellinor","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Mass General Brigham  Boston Massachusetts USA"},{"name":"Demoulas Center for Cardiac Arrhythmias, Mass General Brigham  Boston Massachusetts USA"},{"name":"Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316340"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23983"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h7013"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-06954-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4482"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041705"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0693"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.123.004181"},{"key":"e_1_2_12_12_1","unstructured":"Cardiovascular Disease Knowledge Portal \u201cGene ADAM15 \u201daccessed June 9 2026 https:\/\/cvd.hugeamp.org\/gene.html?gene\u2009=\u2009ADAM15."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.08.001"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2021.12.002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19411"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.252205"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.16.5614-5624.2003"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.08.026"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00756.2009"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-123"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01764-w"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0602.103639"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.08.019"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316363"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385\u2010020\u20100325\u20103"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314600"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.10.033"},{"key":"e_1_2_12_28_1","first-page":"363","article-title":"ADAM15 in Fibroblasts: Improving the Matrix Remodeling by Blocking the Action of Transforming Growth Factor\u2010\u03b21","volume":"54","author":"Li Y.","year":"2024","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44336"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70114-9"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.11.1508"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.168997"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.08.021"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511175112"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01977-z"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.732952"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.70259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eci.70259","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.70259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:20:25Z","timestamp":1791433225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.70259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/eci.70259"],"URL":"https:\/\/doi.org\/10.1111\/eci.70259","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70259"}}