{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:50:27Z","timestamp":1791435027938,"version":"4.3.3"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To the best of our knowledge, no previous systematic review has comprehensively quantified cancer prevalence across the broad spectrum of cardiovascular and cardiometabolic conditions included in the present study. We aimed to estimate pooled prevalence of active cancer (primary outcome) and other cancer categories among patients with coronary artery disease (CAD), heart failure (HF), atrial fibrillation (AF), hypertension, Type 2 diabetes mellitus (DM), stroke, peripheral artery disease (PAD), and valvular heart disease (VHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Web of Science, and Scopus were searched from 2010 to July 2024. Secondary outcomes included prevalence of any, previous, haematological, solid, and metastatic cancer. Prevalence estimates were calculated using one\u2010step generalized linear mixed models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 676 studies comprising approximately 180 million participants were included. The primary analysis of active cancer included 59 studies (4,759,695 patients). Active cancer prevalence ranged from 4.22% (95% confidence interval [CI] 2.18\u20135.32) in Type 2 DM to 5.55% (95% CI 3.97\u20137.01) in AF. The prevalence of any cancer, a secondary outcome with more heterogeneous ascertainment, ranged from 7.04% (95% CI 6.05\u20138.03) in CAD to 14.10% (95% CI 12.20\u201315.99) in AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cancer represents a substantial comorbidity across cardiovascular and cardiometabolic conditions. Although cancer ascertainment methods varied across studies, particularly for any cancer, the findings provide contemporary estimates of cancer burden that may inform future cardio\u2010oncology research, healthcare planning, risk stratification, and the design of cardiovascular and cardiometabolic clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PROSPERO CRD42023494764<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70260","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:41:12Z","timestamp":1789490472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Cancer Across Cardiovascular and Cardiometabolic Conditions: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1605-9512","authenticated-orcid":false,"given":"Akhmetzhan","family":"Galimzhanov","sequence":"first","affiliation":[{"name":"Department of Internal Medicine No 1 Astana Medical University  Astana Kazakhstan"},{"name":"Keele Cardiovascular Research Group, Keele University  Keele UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Beytekin","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Keele University  Keele UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5825-7325","authenticated-orcid":false,"given":"Leh Chuan","family":"Lim","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Keele University  Keele UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Basit Ali","family":"Zai","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Keele University  Keele UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-2690","authenticated-orcid":false,"given":"Gemina","family":"Doolub","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Keele University  Keele UK"},{"name":"University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4600-2701","authenticated-orcid":false,"given":"Mustafa","family":"Al\u2010jarshawi","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Keele University  Keele UK"},{"name":"Centre for Health Informatics, Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-0744","authenticated-orcid":false,"given":"Balamrit Singh","family":"Sokhal","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Keele University  Keele UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9272-6906","authenticated-orcid":false,"given":"Andrija","family":"Matetic","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Keele University  Keele UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1888-9429","authenticated-orcid":false,"given":"Rodrigo","family":"Bagur","sequence":"additional","affiliation":[{"name":"Department of Cardiology London Health Sciences Centre, Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3381-3115","authenticated-orcid":false,"given":"Louise Y.","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Anesthesiology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8297-1569","authenticated-orcid":false,"given":"Cheng Han","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"},{"name":"Division of Gastroenterology, Department of Medicine Kurume University School of Medicine  Kurume Japan"},{"name":"Graduate School of Medicine, Yokohama City University  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8363-0363","authenticated-orcid":false,"given":"Miguel Nobre","family":"Menezes","sequence":"additional","affiliation":[{"name":"Structural and Coronary Heart Disease Unit, Cardio\u2010Oncology Unit CHULN Hospital de Santa Maria Cardiovascular Center of the University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-583X","authenticated-orcid":false,"given":"Sarah","family":"Zaman","sequence":"additional","affiliation":[{"name":"Westmead Applied Research Centre, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6628-9981","authenticated-orcid":false,"given":"Bonnie","family":"Ky","sequence":"additional","affiliation":[{"name":"Thalheimer Center for Cardio\u2010Oncology, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Keele University  Keele UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.08.015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.124.319863"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020406"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1453090"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2024.07.016"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-025-10531-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac244"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2025.05.014"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.10.040"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2024.101080"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45014-4"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73668-y"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2196\/40149"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17203301"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2022.100026"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2022-321324"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03273-3"},{"key":"e_1_2_11_20_1","first-page":"16","article-title":"A Novel Cardio\u2010Oncology Service Line Model in Optimizing Care Access, Quality and Equity for Large, Multi\u2010Hospital Health Systems","volume":"9","author":"Liu Y.","year":"2023","journal-title":"Cardiooncology"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cl2.1230"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S497760"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd12.150274"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2023.131339"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.06.037"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-022-01694-7"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.12.014"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-1-15"},{"key":"e_1_2_11_31_1","unstructured":"\u201cWebsite \u201dhttps:\/\/www.cochrane.org\/authors\/handbooks\u2010and\u2010manuals\/handbook."},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.15171\/ijhpm.2014.71"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000001232"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4040"},{"key":"e_1_2_11_36_1","unstructured":"\u201cWebsite \u201dhttps:\/\/unstats.un.org\/sdgs\/indicators\/regional\u2010groups\/."},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000141"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1714"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-021-01381-z"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.12.023"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1245"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116450"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2020.0250"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2536"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033603"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwad243"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013754"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2025.06.005"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01408-6"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508328"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0964-7"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-8-79"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1547"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.70260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eci.70260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.70260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:20:19Z","timestamp":1791433219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.70260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/eci.70260"],"URL":"https:\/\/doi.org\/10.1111\/eci.70260","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70260"}}