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Lipid\u2010lowering therapy represents the cornerstone of cardiovascular prevention, with low\u2010density lipoproteins (LDL) identified as a causal factor in atherosclerosis. Last decades have seen a rapid expansion in therapeutic options beyond statins, including ezetimibe, bempedoic acid, proprotein convertase subtilisin\/kexin Type 9 inhibitors, both monoclonal antibodies and small interfering RNA therapies, and emerging agents targeting novel pathways. Current treatment paradigms emphasize early risk stratification, aggressive LDL\u2010cholesterol (LDL\u2010C) control in high\u2010risk individuals and systematic combination therapy when treatment goals cannot be achieved with statins alone. In addition, growing attention is being paid to residual cardiovascular risk associated with triglyceride\u2010rich lipoproteins and lipoprotein (a) [Lp(a)]. 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