{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:15:18Z","timestamp":1789726518144,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evolution and Development"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:label\/><jats:p>Few skeletal structures are as informative of the adaptive natural history of vertebrate animals as their teeth. Understanding principles of tooth development is key to understanding evolution of the vertebrate dentition in general and emergence of multiple specialized tooth types in particular. Morphological and phylogenetic considerations suggest that crocodilians have the most primitive mode of dentition within extant tetrapods, displaying simple, conical, socketed, and continuously replaced teeth. Previous histological studies revealed several dental fates, including functional and non\u2010functional teeth (rudiments) in the developing alligator embryos. We analyze expression of key odontogenic regulators and markers to better characterize the molecular patterning of crocodilian dentition. Importantly, we demonstrate that the morphologically distinct tooth types in <jats:italic>Alligator mississippiensis<\/jats:italic> are distinguishable by differences in their developmental programs. We also present evidence showing that tooth maturation is accompanied by dynamic gene expression in the epithelial and mesenchymal cells involved in tooth development. Our data reveal a significant morphological and genetic variation in early dental fates. We believe that this underlying developmental variation reflects modularity, or the ability of teeth to develop semi\u2010autonomously along the alligator jaw. We propose that such modularity may have been a crucial for adaptive evolution within Amniota, allowing for the progressive modifications to tooth replacement, number, and shape.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ede.12049","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T08:57:56Z","timestamp":1385110676000},"page":"393-405","source":"Crossref","is-referenced-by-count":14,"title":["Molecular characterization of dental development in a toothed archosaur, the American alligator <i>Alligator mississippiensis<\/i>"],"prefix":"10.1111","volume":"15","author":[{"given":"Olivia","family":"Weeks","sequence":"first","affiliation":[{"name":"Department of Organismic and Evolutionary Biology Harvard University 16 Divinity Avenue Cambridge MA 02138 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhart\u2010Anjan S.","family":"Bhullar","sequence":"additional","affiliation":[{"name":"Department of Organismic and Evolutionary Biology Harvard University 16 Divinity Avenue Cambridge MA 02138 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arhat","family":"Abzhanov","sequence":"additional","affiliation":[{"name":"Department of Organismic and Evolutionary Biology Harvard University 16 Divinity Avenue Cambridge MA 02138 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"25","article-title":"Ontogenetic aspects of dental evolution","volume":"39","author":"Butler P. 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