{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:48:00Z","timestamp":1790837280735,"version":"4.1.0"},"reference-count":104,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evolution and Development"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:label\/><jats:p>The processes that direct skull remodeling are of interest to both human\u2010oriented studies of cranial dysplasia and evolutionary studies of skull divergence. There is increasing awareness that these two fields can be mutually informative when natural variation mimics pathology. Here we describe a zebrafish mutant line, <jats:italic>devoid of blastema<\/jats:italic> (<jats:italic>dob<\/jats:italic>), which does not have a functional fgf20a protein, and which also presents cranial defects similar to both adaptive and clinical variation. We used geometric morphometric methods to provide quantitative descriptions of the effects of the <jats:italic>dob<\/jats:italic> mutation on skull morphogenesis. In combination with \u201cwhole\u2010mount in situ hybridization\u201d labeling of normal <jats:italic>fgf20a<\/jats:italic> expression and assays for osteoblast and osteoclast activity, the results of these analyses indicate that cranial dysmorphologies in <jats:italic>dob<\/jats:italic> zebrafish are generated by aberrations in post\u2010embryonic skull remodeling via decreased osteoblasotgenesis and increased osteoclastogenesis. Mutational effects include altered skull vault geometries and midfacial hypoplasia that are consistent with key diagnostic signs for multiple human craniofacial syndromes. These phenotypic shifts also mimic changes in the functional morphology of fish skulls that have arisen repeatedly in several highly successful radiations (e.g., damselfishes and East\u2010African rift\u2010lake cichlids). Our results offer the <jats:italic>dob\/fgf20a<\/jats:italic> mutant as an experimentally tractable model with which to examine post\u2010embryonic skull development as it relates to human disease and vertebrate evolution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ede.12052","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T08:57:56Z","timestamp":1385110676000},"page":"426-441","source":"Crossref","is-referenced-by-count":24,"title":["Deficiency of zebrafish <i>fgf20a<\/i> results in aberrant skull remodeling that mimics both human cranial disease and evolutionarily important fish skull morphologies"],"prefix":"10.1111","volume":"15","author":[{"given":"W. James","family":"Cooper","sequence":"first","affiliation":[{"name":"School of Biological Sciences Washington State University Tri\u2010Cities Richland WA 99354 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Wirgau","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Washington State University Tri\u2010Cities Richland WA 99354 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elly M.","family":"Sweet","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Washington State University Tri\u2010Cities Richland WA 99354 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Craig","family":"Albertson","sequence":"additional","affiliation":[{"name":"Department of Biology University of Massachusetts Amherst MA 01003 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.1998.tb00970.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12035"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2008.11.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(04)76019-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.03.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1163\/002829676X00019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00644.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2792"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2005.3276"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(98)00104-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.320"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000680204"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01227"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600460"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31731"},{"key":"e_1_2_7_17_1","first-page":"455","article-title":"Phylogeny of recent billfishes (Xiphioidei)","volume":"79","author":"Collette B. B.","year":"2006","journal-title":"Bull. Mar. Sci."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.06.025"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009551"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11692-011-9124-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-9-24"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304698200"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22629"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.2006.00681.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icq071"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.04.021"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952836903003819"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp060097h"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/42.2.265"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0094837300014056"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0633.1998.tb00185.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1095-8649.2003.00100.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20161"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.05.513"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2010.2031"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1365.035"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00656-6"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00940"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.59540"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8644(200001)111:1<105::AID-AJPA7>3.0.CO;2-O"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00114-010-0682-y"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/42.2.222"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.04.048"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.5.776"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.17.3375"},{"key":"e_1_2_7_46_1","first-page":"23","article-title":"Phenotypic diversity in patients with craniosynostoses unrelated to Apert syndrome: the role of fibroblast growth factor receptor gene mutations","volume":"102","author":"Ito S.","year":"2005","journal-title":"J. Neurosurg."},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2004.08.007"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-007-0006-6"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.97"},{"key":"e_1_2_7_50_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3892\/or.14.1.291","article-title":"Comparative genomics on FGF20 orthologs","volume":"14","author":"Katoh M.","year":"2005","journal-title":"Oncol. Rep."},{"key":"e_1_2_7_51_1","first-page":"163","article-title":"FGF signaling network in the gastrointestinal tract (Review)","volume":"29","author":"Katoh M.","year":"2006","journal-title":"Int. J. Oncol."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2001.19910105.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0201"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.2007.00893.x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.2002.tb02086.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.12.002"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.08.071"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.965602"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.1999.tb05413.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00005908"},{"key":"e_1_2_7_61_1","first-page":"868","volume-title":"Pediatric Bone: Biology and Diseases","author":"Maes C.","year":"2011"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011480108"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00317461"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026425"},{"key":"e_1_2_7_65_1","volume-title":"Plastic Surgery","author":"McCarthy J. G.","year":"1990"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq045"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00475.x"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.2307\/1446952"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2548"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.965702"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1420-9101.2004.00844.x"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-387036-0.00011-6"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007957"},{"key":"e_1_2_7_74_1","volume-title":"Clearing and Staining Technique. Ontogeny and Systematics of Fishes","author":"Pothoff T.","year":"1983"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091100"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.2007.00915.x"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01779"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1139\/f02-144"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01237641"},{"key":"e_1_2_7_80_1","unstructured":"Rohlf F. J.2006. tpsDig2.http:\/\/life.bio.sunysb.edu\/morph\/%5D"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.10023"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.1996.tb01434.x"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.1998.tb00355.x"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.1.6442"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21388"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20581"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328133265b"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.15.2945"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0426.2010.01401.x"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1086\/285404"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.4.676"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-13-1-66"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1071\/MF07026"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1086\/421052"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.2004.00313.x"},{"key":"e_1_2_7_96_1","first-page":"3","article-title":"Ecological morphology of lacustrine threespine stickleback Gasterosteus aculeatus L (Gasterosteidae) body shape","volume":"61","author":"Walker J. A.","year":"1997","journal-title":"Biol. J. Linn. Soc."},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7998.2000.tb00624.x"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10385"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-257"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00005920"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(03)00058-4"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117637"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1086\/590966"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.052340"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2002.1960"}],"container-title":["Evolution &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fede.12052","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ede.12052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:41:14Z","timestamp":1696336874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ede.12052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":104,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/ede.12052"],"URL":"https:\/\/doi.org\/10.1111\/ede.12052","archive":["Portico"],"relation":{},"ISSN":["1520-541X","1525-142X"],"issn-type":[{"value":"1520-541X","type":"print"},{"value":"1525-142X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}