{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:49:31Z","timestamp":1785350971333,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evolution and Development"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The question of whether \u201cdevelopmental bias\u201d can influence evolution is still controversial, despite much circumstantial evidence and a good theoretical argument. Here, I will argue that the domestication of mammalian species, which took place independently more than two dozen times, provides a particularly convincing example of developmental bias in evolution. The singular finding that underlies this claim is the repeated occurrence in domesticated mammals of a set of distinctive traits, none of which were deliberately selected. This phenomenon has been termed \u201cthe domestication syndrome\u201d. In this article, I will: (a) describe the properties of the domestication syndrome; (b) show how it can be explained in terms of the operation of a specific genetic regulatory network, that which governs neural crest cell development; and (c) discuss Dmitry Belyaev's idea of \u201cdestabilizing selection,\u201d which holds that selecting for a new behavior often entails neuroendocrine alterations that alter many aspects of development. Finally, I will argue for the potential general significance of such destabilizing selection, in combination with developmental bias, in animal evolution.<\/jats:p>","DOI":"10.1111\/ede.12319","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T10:29:12Z","timestamp":1569234552000},"page":"143-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["A striking example of developmental bias in an evolutionary process: The \u201cdomestication syndrome\u201d"],"prefix":"10.1111","volume":"22","author":[{"given":"Adam S.","family":"Wilkins","sequence":"first","affiliation":[{"name":"Institute of Theoretical Biology Humboldt Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"e_1_2_11_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.applanim.2017.09.006"},{"key":"e_1_2_11_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45532-2_15"},{"key":"e_1_2_11_1_4_1","doi-asserted-by":"crossref","unstructured":"Alberch P.(1989). The logic of monsters: evidence for internal constraint in development and evolution. In B. David J.L. Dommergues J. Chaline and B. Laurin (Eds.) \u00a0Ontogenese et Evolution.Geobios Mem. 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