{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:39Z","timestamp":1787014119094,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dentoalveolar ankylosis with osseous replacement is often seen after replantation of avulsed teeth, and this process may be used for preservation of alveolar crests after trauma. Its exact mechanisms with regard to osteoinductive properties are not yet fully understood and need to be systematically investigated. Dentin can possibly act as a slow\u2010releasing carrier of bone morphogenic proteins (\n                    <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\n                    ), and this property of dentin has been proposed to be used as an alternative or supplement to bone grafting in the maxillofacial region. We aimed to initially asses host tissue reactions to dentin by implanting dentin blocks of autogenic and xenogenic human origin in rabbit connective tissue of the abdominal wall and femoral muscle. Animals were sacrificed after a period of 3\u00a0months, and histological processing, sectioning and examinations were carried out. Bone formation, cell counts and thickness of capsule surrounding the grafts were evaluated. Only minor signs of heterotopic bone formation were seen. There were no significant differences between autografts and xenografts or grafts implanted in connective tissue or muscle with regards to tissue reactions except for a significant difference (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.018) in findings of more local inflammatory cells in relation to grafts placed in connective tissue in the autograft group. We conclude that during the time frame of this study, non\u2010demineralized dentin, whether autogenous or xenogenic did not have the potential to induce bone formation when implanted in non\u2010osteogenic areas such as the abdominal wall and abdominal muscle of rabbits.\n                  <\/jats:p>","DOI":"10.1111\/edt.12066","type":"journal-article","created":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T21:32:02Z","timestamp":1378071122000},"page":"198-203","source":"Crossref","is-referenced-by-count":15,"title":["Host tissue reactions of non\u2010demineralized autogenic and xenogenic dentin blocks implanted in a non\u2010osteogenic environment. An experimental study in rabbits"],"prefix":"10.1111","volume":"30","author":[{"given":"Adel","family":"Al\u2010Asfour","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences Faculty of Dentistry Kuwait University Safat Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Farzad","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Faculty of Dentistry Kuwait University Safat Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences Faculty of Dentistry Kuwait University Safat Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Dahlin","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute for Surgical Sciences The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356609028222"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(84)80069-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1985.tb00552.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1989.tb00335.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2011.01003.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2012.01125.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4477.1999.tb00088.x"},{"key":"e_1_2_6_9_1","first-page":"391","article-title":"Surgical treatment of ankylosed and infrapositioned reimplanted incisors in adolescents","volume":"92","author":"Malmgren B","year":"1984","journal-title":"Scand J Dent Res"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2008.00703.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2010.00912.x"},{"key":"e_1_2_6_12_1","first-page":"361","article-title":"Alveolar ridge augmentation by osteoinductive materials in goats","volume":"6","author":"Pinholt EM","year":"1992","journal-title":"Scand J Dent Res"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1563\/1548-1336(1998)024<0124:RDRMFA>2.3.CO;2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/03008200390151927","article-title":"Use of bone morphogenetic protein\u20102 and dentin matrix protein\u20101 to enhance the osteointegration of the Onplant system","volume":"1","author":"Hassan AH","year":"2003","journal-title":"Connect Tissue Res"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310179200"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.06.670"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.11.021"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181cdd396"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/edt.12045"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367789780886858"},{"key":"e_1_2_6_21_1","first-page":"284","article-title":"The implantation of decalcified human dentin and cementum into subcutaneous tissues of the rat","volume":"2","author":"Morris ML","year":"1957","journal-title":"J Periodont Res"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(00)00051-2"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(67)90095-7"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80204-6"},{"key":"e_1_2_6_25_1","first-page":"563","article-title":"Histologic evaluation of the osteoinductive property of autogenous demineralised dentin matrix on surgical bone defects in rabbit skulls using human amniotic membrane for guided bone regeneration","volume":"16","author":"Gomes MF","year":"2001","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_26_1","first-page":"450","article-title":"Dentin as an ossicular substitute. Experimental results in animals","volume":"81","author":"Stewart IA","year":"1976","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01136.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1967.01330120035008"},{"key":"e_1_2_6_29_1","first-page":"60","article-title":"Induction of heterotopic bone formation by demineralised dentin in guinea pigs: relation to time","volume":"236","author":"Bang G","year":"1973","journal-title":"Acta Pathol Microbiol Scand"},{"key":"e_1_2_6_30_1","first-page":"88","article-title":"Bone histogenesis and morphogenesis in implants of demineralised enamel and dentin","volume":"29","author":"Urist M","year":"1971","journal-title":"J Oral Surg"},{"key":"e_1_2_6_31_1","first-page":"86","article-title":"Use of particulate dentin\u2010plaster of Paris combination with\/without platelet\u2010rich plasma in the treatment of bone defects around implants","volume":"1","author":"Kim SG","year":"2002","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1054\/jcms.2001.0236"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1967.tb01899.x"},{"key":"e_1_2_6_34_1","first-page":"679","article-title":"Histomorphometric analysis of homogenous demineralized dentin matrix as osteopromotive material in rabbit mandibles","volume":"19","author":"Carvalho VA","year":"2004","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_35_1","first-page":"488","article-title":"Autogenous demineralized dentin matrix for tissue engineering applications: radiographic and histomorphometric studies","volume":"17","author":"Gomes MF","year":"2002","journal-title":"Int J Oral Maxillofac Implants"}],"container-title":["Dental Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fedt.12066","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/edt.12066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:29:35Z","timestamp":1696282175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/edt.12066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/edt.12066"],"URL":"https:\/\/doi.org\/10.1111\/edt.12066","archive":["Portico"],"relation":{},"ISSN":["1600-4469","1600-9657"],"issn-type":[{"value":"1600-4469","type":"print"},{"value":"1600-9657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}