{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:17:51Z","timestamp":1778354271727,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontal ligament (<jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>) healing and long term prognosis of replanted avulsed teeth should rely on several factors including length of extra\u2010oral dry time and type of the storage medium. The status of periodontal ligament is critical for the healing of replanted teeth. Different substances have been used for root surface treatment to promote formation of <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content> and increase the survival of avulsed teeth submitted to replantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to assess the effect of recombinant basic fibroblast growth factor 2 (<jats:styled-content style=\"fixed-case\">bFGF<\/jats:styled-content>) and enamel matrix derivative (EMD) on root resorption after delayed replantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>18 freshly extracted single\u2010rooted incisor and premolar teeth were extracted from the beagle dogs and immersed in whole bovine milk for 45 and 60\u00a0min (<jats:italic>n<\/jats:italic>\u00a0=\u00a03 each). Following storage period, sockets washed and teeth were treated with <jats:styled-content style=\"fixed-case\">bFGF<\/jats:styled-content> and EMD and replanted into the sockets. After 8\u00a0weeks, dogs were sacrificed, specimens processed to 4\u2010\u03bcm thick serial sections for histopathologic examination and morphometric assessments. Thus, the proportions of the roots that exhibited signs of surface resorption, inflammatory resorption, and replacement resorption, that is, ankylosis and normal PDL were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage of root resorption was in the following order: EMD&gt;milk&gt;<jats:styled-content style=\"fixed-case\">bFGF<\/jats:styled-content> for 45 min and milk&gt;EMD&gt;<jats:styled-content style=\"fixed-case\">bFGF<\/jats:styled-content> for 60\u00a0min. For all groups, teeth stored 60\u00a0min showed significantly higher incidence of PDL resorption than those stored for 45\u00a0min (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). The highest incidence of replacement resorption was observed in teeth treated with EMD for 60\u00a0min. After 8\u00a0weeks, the least resorption was found in <jats:styled-content style=\"fixed-case\">bFGF<\/jats:styled-content>\u2010treated group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of this study suggest that use of <jats:styled-content style=\"fixed-case\">bFGF<\/jats:styled-content> favored the formation of new periodontal ligament; prevent ankylosis and resorption process following delayed replantation of teeth while EMD shows replacement resorption, which may turn to ankylosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/edt.12141","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T11:44:07Z","timestamp":1412682247000},"page":"49-56","source":"Crossref","is-referenced-by-count":32,"title":["Effect of fibroblast growth factor and enamel matrix derivative treatment on root resorption after delayed replantation"],"prefix":"10.1111","volume":"31","author":[{"given":"Elif Bahar","family":"Tuna","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry Nihon University School of Dentistry at Matsudo Chiba Japan"},{"name":"Department of Pedodontics Istanbul University Faculty of Dentistry Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Nihon University School of Dentistry at Matsudo Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merva Soluk","family":"Tekkesin","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology Institute of Oncology Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Seymen","sequence":"additional","affiliation":[{"name":"Department of Pedodontics Istanbul University Faculty of Dentistry Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koray","family":"Gencay","sequence":"additional","affiliation":[{"name":"Department of Pedodontics Istanbul University Faculty of Dentistry Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Kuboyama","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Nihon University School of Dentistry at Matsudo Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Nihon University School of Dentistry at Matsudo Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2010.00879.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2008.00648.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.07.055"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200012000-00005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2006.00338.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1995.tb00464.x"},{"key":"e_1_2_6_8_1","first-page":"27","article-title":"Saad Neto M, Sonoda CK, Poi WR, Carvalho ACP. 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