{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:47:39Z","timestamp":1777956459131,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:00:00Z","timestamp":1433980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Trauma is one of the primary causes of tooth loss and pulpal injury in adolescents and children. Prior to regenerative endodontics, treatment of necrotic, immature teeth with open apices was limited to long\u2010term calcium hydroxide (Ca(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>) apexification and subsequent root canal therapy or extraction. Through revascularization, retention of these teeth can be achieved and the elimination of patient symptoms and the radiographic appearance of continued root development were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Review<\/jats:title><jats:p>This report illustrates a revascularization protocol through a case where platelet\u2010rich fibrin (<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>) was utilized as an autologous scaffold for traumatized, necrotic, immature teeth with incomplete root development. Through consistent follow\u2010up reports, comprising of both clinical examination and radiographs, marked improvement in the condition of the traumatized tooth was noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This case demonstrates the feasibility of utilizing <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> as an effective treatment protocol for traumatized teeth in lieu of traditional treatment protocols, such as long\u2010term calcium hydroxide (Ca(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>) apexification or extraction. The choice of utilizing <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>, as opposed to other platelet concentrates, such as platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) or a blood clot, lies in <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>'s ability to allow for a slow, long\u2010term release of autologous growth factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/edt.12189","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T16:56:28Z","timestamp":1434732988000},"page":"80-84","source":"Crossref","is-referenced-by-count":37,"title":["Long\u2010term follow up of revascularization using platelet\u2010rich fibrin"],"prefix":"10.1111","volume":"32","author":[{"suffix":"Jr","given":"Herbert L","family":"Ray","sequence":"first","affiliation":[{"name":"Center for Craniofacial Regeneration McGowan Institute of Regenerative Medicine Pittsburgh PA USA"},{"name":"Department of Endodontics University of Pittsburgh School of Dental Medicine Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janel","family":"Marcelino","sequence":"additional","affiliation":[{"name":"Department of Endodontics University of Pittsburgh School of Dental Medicine Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Endodontics University of Pittsburgh School of Dental Medicine Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Horwat","sequence":"additional","affiliation":[{"name":"Department of Endodontics University of Pittsburgh School of Dental Medicine Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lisien","sequence":"additional","affiliation":[{"name":"Department of Endodontics University of Pittsburgh School of Dental Medicine Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahryar","family":"Khaliq","sequence":"additional","affiliation":[{"name":"Department of Endodontics University of Pittsburgh School of Dental Medicine Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511434355"},{"key":"e_1_2_7_3_1","first-page":"15","article-title":"Incidence of traumatic tooth injuries in children and adolescents in the county of Vastmanland, Sweden","volume":"20","author":"Glendor U","year":"1996","journal-title":"Swed Dent J"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2002.00097.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1992.tb00228.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.06.028"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.10.032"},{"key":"e_1_2_7_8_1","first-page":"333","article-title":"Tissue formation in the root canal following pulp removal","volume":"79","author":"Nygaard\u2010Ostby B","year":"1971","journal-title":"Scand J Dent Res"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356109043395"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90119-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2004.00284.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-0707.94582"},{"key":"e_1_2_7_13_1","first-page":"47","article-title":"Pulp revascularization of a necrotic infected immature permanent tooth: case report and review of the literature","volume":"29","author":"Thibodeau B","year":"2007","journal-title":"Pediatr Dent"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1996.tb01172.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1996.tb01173.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.don.0000148143.80283.ea"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.09.015"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.02.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200404000-00003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.05.033"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.01.011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.11.004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12107"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.09.019"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.08.027"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0327"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.06.018"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.09.007"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.06.044"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.09.012"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.03.001"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00618-X"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.02.004"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.09.001"}],"container-title":["Dental Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fedt.12189","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/edt.12189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:55:08Z","timestamp":1696359308000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/edt.12189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,11]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/edt.12189"],"URL":"https:\/\/doi.org\/10.1111\/edt.12189","archive":["Portico"],"relation":{},"ISSN":["1600-4469","1600-9657"],"issn-type":[{"value":"1600-4469","type":"print"},{"value":"1600-9657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,11]]}}}