{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:41:09Z","timestamp":1762623669405},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2012\u2010003155"],"award-info":[{"award-number":["2012\u2010003155"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aim<\/jats:title><jats:p>In this study, we evaluated whether zoledronate could suppress the progression of external root resorption in rat due to delayed replantation by inhibiting osteoclastic activity. Also, we estimated the optimal dosage of zoledronate in root treatment of the rat model for a maximum effect of zoledronate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Maxillary first molars in Sprague Dawley rats (<jats:italic>N<\/jats:italic>\u00a0=\u00a084) were extracted, dried for 60\u00a0min, and then replanted. The rats were divided into 6 groups (1\u00a0mM alendronate, and 1, 5, 10, 20, 40\u00a0\u03bcM zoledronate). At 4 and 8\u00a0weeks postreplantation, the animals were sacrificed and evaluated by radiographic and histological analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusion<\/jats:title><jats:p>There were no significant differences at 4\u00a0weeks. However, at 8\u00a0weeks, 10, 20, and 40\u00a0\u03bcM <jats:styled-content style=\"fixed-case\">ZOL<\/jats:styled-content> showed more increased radiopaque and smaller periapical lesion in radiographic analysis. In histological analysis, all groups showed similar inflammatory root resorption rate at 4\u00a0weeks. However, at 8\u00a0weeks, 20 and 40\u00a0\u03bcM <jats:styled-content style=\"fixed-case\">ZOL<\/jats:styled-content> showed lower rate than those of other groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In concerning of replacement resorption, there were no significant differences statistically. In this animal experiment, zoledronate was capable of limiting the occurrence of root resorption in delayed replantation model. In particular, 20\u00a0\u03bcM dosage of zoledronate solution showed the most effective dose in long\u2010term follow up and might be suitable for inhibition of root resorption in delayed tooth replantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/edt.12202","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T09:23:35Z","timestamp":1436261015000},"page":"465-470","source":"Crossref","is-referenced-by-count":7,"title":["Could zoledronic acid prevent root resorption in replanted rat molar?"],"prefix":"10.1111","volume":"31","author":[{"given":"Jung Eun","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry School of Dentistry Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry School of Dentistry Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2013dae","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery School of dentistry Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Tissue Regeneration and Research Center for Tooth &amp; Periodontal Regeneration (MRC) School of Dentistry Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Kyung Hee University Dental Hospital, Gangdong Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Chul","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry School of Dentistry 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