{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T01:18:26Z","timestamp":1768526306723,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effect of paracrine factors secreted from human bone marrow stromal cell (<jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>) on pulpal and periodontal healing following immediate replantation of maxillary rat first molars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Fifty maxillary rat first molars were elevated and replanted after 2\u00a0min. The left teeth were replanted without treatment, whereas <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> was injected into the right socket prior to replantation. Twelve un\u2010operated teeth served as reference teeth. The expression of vascular endothelial growth factor A, alkaline phosphatase, Runt\u2010related transcription factor 2 and osteoclast stimulating factor 1 was studied by real\u2010time reverse transcription polymerase chain reaction at day 3 and 14. The dentin thickness together with Laminin\u2010 and <jats:styled-content style=\"fixed-case\">PGP<\/jats:styled-content> 9.5\u2010immunoreactivity were studied after 3, 14 and 90\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Real\u2010Time qRT\u2010PCR data showed up\u2010regulated expression of <jats:styled-content style=\"fixed-case\">ALP mRNA<\/jats:styled-content> in the socket specimens of conditioned medium treated replanted teeth after 3\u00a0days. No morphological differences were found for the expression of Laminin and <jats:styled-content style=\"fixed-case\">PGP<\/jats:styled-content> 9.5 between control and conditioned medium treated replanted teeth. At day 14, external cervical and surface root resorption was found in one <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> and one control tooth. At 90\u00a0days, all control replanted teeth had external cervical and surface root resorptions, whereas only one sample was seen among the conditioned medium treated teeth. At day 90, more extensive dentine formation with narrowing of the pulpal space was observed in the control compared with conditioned medium treated teeth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present findings showed that <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> treatment reduced the number of replanted teeth with external root resorption and resulted in a significant reduction in new dentin formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/edt.12246","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T20:59:13Z","timestamp":1449781153000},"page":"231-239","source":"Crossref","is-referenced-by-count":7,"title":["Influence of bone marrow stromal cell secreted molecules on pulpal and periodontal healing in replanted immature rat molars"],"prefix":"10.1111","volume":"32","author":[{"given":"Niyaz","family":"Al\u2010Sharabi","sequence":"first","affiliation":[{"name":"Department of Clinical Dentistry Center for Clinical Dental Research University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry Center for Clinical Dental Research University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minora","family":"Udea","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Nagoya Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry Center for Clinical Dental Research University of Bergen Bergen 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