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Considering recent findings of occlusal loading\u2010related regional heterogeneity in the mid\u2010facial bone micro\u2010architecture, the aim of this study was to explore whether such heterogeneity in cortical and cancellous bone micro\u2010architecture may contribute to increased fragility at Le Fort fracture sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010five cortical and thirteen cancellous bone specimens were harvested from a dry skull and analyzed by micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>. Specimens were classified into Le Fort or Non\u2010Le Fort groups based on their location in the mid\u2010facial skeleton.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cortical bone along Le Fort lines showed tendencies toward lower thickness (1.5\u00b10.63 vs 1.75\u00b10.79; <jats:italic>P<\/jats:italic>=.39) and greater porosity (11.48\u00b15.67 vs 10.28\u00b15.28; <jats:italic>P<\/jats:italic>=.59). A significant difference was detected in the trabecular degree of anisotropy which was higher in cancellous bone from Le Fort fracture sites (2.14\u00b10.69 vs 1.58\u00b10.34; <jats:italic>P<\/jats:italic>=.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Regional heterogeneity in cortical bone micro\u2010architecture could not fully explain increased fragility of the mid\u2010facial skeleton at the Le Fort lines. 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