{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:46:32Z","timestamp":1762623992931,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015R1C1A2A01054748"],"award-info":[{"award-number":["2015R1C1A2A01054748"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aim<\/jats:title><jats:p>Continuous research efforts have been focusing on promoting healing of delayed replantation of avulsed teeth. The aim of this in vivo study was to assess the effect of cathepsin K inhibitor surface treatment on delayed tooth replantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010four premolar roots of 4 beagle dogs were extracted, and conventional root canal treatment was performed. The canals were filled with gutta\u2010percha and cement. All extracted teeth were air\u2010dried for 1\u00a0hour. Teeth were divided into 2 groups according to the root surface treatment prior to replantation: control (n\u00a0=\u00a013) and cathepsin K inhibitor (n\u00a0=\u00a021). Treated teeth were replanted in their original sockets and stabilized with a resin\u2010wire splint for 1\u00a0week. After 12\u00a0weeks, the dogs were euthanized and micro\u2010computed tomography was performed. Tissues were then further processed as resin\u2010embedded specimens stained with hematoxylin and eosin. In each evaluation, data were analyzed using the Mann\u2010Whitney <jats:italic>U<\/jats:italic> test (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the micro\u2010computed tomography evaluation, inflammation scores of both groups were not statistically different (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a0.05). In the histological evaluation, the mean proportions of inflammatory resorption and replacement resorption in the control group were similar to those in the cathepsin K inhibitor group (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cathepsin K inhibitor did not demonstrate significant inhibitory effects on root resorption after delayed replantation in vivo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/edt.12397","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T11:06:24Z","timestamp":1521111984000},"page":"201-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of cathepsin K inhibitor surface treatment on delayed tooth replantation in dogs"],"prefix":"10.1111","volume":"34","author":[{"given":"Youngil","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry University of Ulsan Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunjung","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry University of Ulsan Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soojung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry University of Ulsan Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-1038","authenticated-orcid":false,"given":"Miri","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry University of Ulsan Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"444","volume-title":"Textbook and Color Atlas of Traumatic Injuries to Teeth","author":"Andreasen JO","year":"2007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1995.tb00464.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(81)80007-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.05.017"},{"key":"e_1_2_8_6_1","unstructured":"American Association of Endodontists.Recommended guidelines of the AAE for the treatment of traumatic dental injuries (revised 2013). 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