{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:48:53Z","timestamp":1755035333717,"version":"3.41.0"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308089\/2012\u20100"],"award-info":[{"award-number":["308089\/2012\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aim<\/jats:title><jats:p>The storage media is directly related to the prognosis of avulsed teeth, with resveratrol drawing attention due to its antioxidant and anti\u2010inflammatory proprieties. The aim of this study was to evaluate the repair process in rat teeth following delayed replantation after storage in resveratrol (R) dissolved in dimethyl sulphoxide (<jats:styled-content style=\"fixed-case\">DMSO<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The upper right central incisors of 36 rats were divided into 4 groups. In group I, the teeth were extracted and immediately replanted. Group<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>teeth were stored in 50\u00a0mL R+<jats:styled-content style=\"fixed-case\">DMSO<\/jats:styled-content>(0.0512\u00a0g\/mL), whereas group<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>teeth were stored in 50\u00a0mL pure<jats:styled-content style=\"fixed-case\">DMSO<\/jats:styled-content>, both for a period of 60\u00a0minutes. The teeth of group<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>were stored dry for 60\u00a0minutes. The teeth of groups<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>were then replanted, and the animals were euthanized after 60\u00a0days. Longitudinal histological cuts were<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>stained for histomorphometric analysis of the periodontal ligament, alveolar bone, cementum and dentin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis of<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>stained histological sections showed the following statistical differences: the acute inflammatory process in the epithelial insertion was less prominent in group<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>than in group<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>; the organization of the periodontal ligament was better in group I, while the intensity and extension of acute inflammation in the periodontal ligament were better in group I, and worse in group<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>; the chronic inflammatory infiltrate was less in groups I and<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>, and the depth and extent of resorption, as well as the repair of root resorption, were better in group I.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Storage in R+<jats:styled-content style=\"fixed-case\">DMSO<\/jats:styled-content>solution did not inhibit root resorption after delayed replantation in rat teeth. It is concluded that pure<jats:styled-content style=\"fixed-case\">DMSO<\/jats:styled-content>is not a suitable transport medium for avulsed teeth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/edt.12402","type":"journal-article","created":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T02:32:48Z","timestamp":1523759568000},"page":"254-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Histological evaluation of the repair process of replanted rat teeth after storage in resveratrol dissolved in dimethyl sulphoxide"],"prefix":"10.1111","volume":"34","author":[{"given":"Wilson R.","family":"Poi","sequence":"first","affiliation":[{"name":"Surgery and Integrated Clinics Faculdade de Odontologia UNESP\u2010Universidade Estadual Paulista Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8639-1767","authenticated-orcid":false,"given":"Celso K.","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Surgery and Integrated Clinics Faculdade de Odontologia UNESP\u2010Universidade Estadual Paulista Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3305-3080","authenticated-orcid":false,"given":"Marina F.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Surgery and Integrated Clinics Faculdade de Odontologia UNESP\u2010Universidade Estadual Paulista Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo F.","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Surgery and Integrated Clinics Faculdade de Odontologia UNESP\u2010Universidade Estadual Paulista Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alline B.","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Surgery and Integrated Clinics Faculdade de Odontologia UNESP\u2010Universidade Estadual Paulista Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela A.","family":"Brandini","sequence":"additional","affiliation":[{"name":"Surgery and Integrated Clinics Faculdade de Odontologia UNESP\u2010Universidade Estadual Paulista Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1994.tb00220.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(81)80007-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1999.tb00793.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1998.00138.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2012.01138.x"},{"key":"e_1_2_7_7_1","first-page":"436","article-title":"Viability of human periodontal ligament cells after storage in milk or saliva","volume":"88","author":"Bloml\u00f6f L","year":"1980","journal-title":"Scand J Dent Res"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2010.00933.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2009.00856.x"},{"key":"e_1_2_7_10_1","first-page":"43","article-title":"Treatment of non vital permanent incisors with calcium hydroxide 3. Variation of occurrence of ankylosis of reimplanted teeth with duration of extra\u2010alveolar period and storage environment","volume":"25","author":"Cvek M","year":"1974","journal-title":"Odontol Revy"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5005\/jcdp-9-6-17"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2009.01591.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.06.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2011.00988.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.03.028"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2011.01054.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345830620081301"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2008.00723.x"},{"key":"e_1_2_7_19_1","first-page":"557","article-title":"Resveratrol, a natural chemopreventive agent against degenerative diseases","volume":"53","author":"Ignatowicz E","year":"2001","journal-title":"Pol J Pharmacol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200589"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2009.01691.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2060"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351156"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0031-6997(24)01472-8","article-title":"The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer","volume":"52","author":"Middleton E","year":"2000","journal-title":"Pharmacol Rev"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.08.003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(02)00005-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01394.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.04.006"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120746"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.14-129"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.10.031"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22588"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05871.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i2.280"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1720-y"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-006-9012-0"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2011.01511.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100761u"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00886-3"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3501"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/09687688.2012.687460"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(75)80158-0"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.006023"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.01.009"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12193"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.04.004"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.11.2851"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.06.016"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12093"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.08.009"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9504576"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.02.037"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425240903071029"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(03)00021-3"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2011.01.020"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2012.12.010"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24264"},{"key":"e_1_2_7_58_1","first-page":"77","volume-title":"Cryopreservation and freeze\u2010drying protocols","author":"Day JG","year":"2007"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0960793"}],"container-title":["Dental Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fedt.12402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/edt.12402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T17:43:46Z","timestamp":1751564626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/edt.12402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,17]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/edt.12402"],"URL":"https:\/\/doi.org\/10.1111\/edt.12402","archive":["Portico"],"relation":{},"ISSN":["1600-4469","1600-9657"],"issn-type":[{"type":"print","value":"1600-4469"},{"type":"electronic","value":"1600-9657"}],"subject":[],"published":{"date-parts":[[2018,5,17]]},"assertion":[{"value":"2018-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}