{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:04:13Z","timestamp":1759773853847,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["431807\/2016\u20107"],"award-info":[{"award-number":["431807\/2016\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aim<\/jats:title><jats:p>In addition to their anti\u2010inflammatory and anti\u2010osteoclastogenesis properties, adrenergic blockers may also have promising anti\u2010resorptive effects that can prevent root resorption when teeth are replanted because of avulsion. The aim of this study was to investigate the effects of phentolamine (Ph) and propranolol (Pr) in gels on the repair process of late replanted rat incisors. A further aim was to evaluate the biocompatibility of both drugs to human periodontal ligament fibroblasts (HPDLFs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Forty\u2010eight maxillary right incisors were extracted from male Wistar rats, stored in paper napkins for 60\u00a0minutes, and randomly allocated to one of eight groups (n\u00a0=\u00a06). The root canal, root surface, and alveolus were treated with 0.75\u00a0\u00b5g\/mL Ph gel (Ph0.75), 10\u00a0\u00b5g\/mL Ph gel (Ph10), 100\u00a0\u00b5g\/mL Ph gel (Ph100), 2.5\u00a0\u00b5g\/mL Pr gel (Pr2.5), 10\u00a0\u00b5g\/mL Pr gel (Pr10), 100\u00a0\u00b5g\/mL Pr gel (Pr100), or sodium carboxymethylcellulose gel (CMC) before replantation. In the control group (CH), only the root canal was treated with calcium hydroxide paste. Thirty days following surgery, the animals were euthanized, and the right hemimaxilla was removed to perform micro\u2010CT and histomorphometric analysis to determine osteoclastic activity. Ethanolic solutions of Ph10 and Pr10 were selected based on the in vivo study, and the viability of HPDLFs stimulated with lipopolysaccharide was determined by MTT assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The micro\u2010CT and histomorphometric analysis revealed no significant differences among the treatments (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). The presence of active osteoclasts was significantly decreased in the Ph10 and Pr10 groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Ph10 and Pr10 produced statistically similar cell survival rates compared to the control group (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ph10 and Pr10 significantly decreased osteoclastogenesis in delayed replanted rat teeth and were not cytotoxic toward HPDLFs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/edt.12523","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T17:26:07Z","timestamp":1571937967000},"page":"253-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2010inflammatory and anti\u2010resorptive efficacy of adrenergic blockers on late replanted rat incisors"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5619-3831","authenticated-orcid":false,"given":"Felipe de Souza","family":"Matos","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry Endodontic Division Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Falchete","family":"do Prado","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry Endodontic Division Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayana Duarte","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry Endodontic Division Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciane Dias","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Carneiro","family":"Valera","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry Endodontic Division Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip Leo","family":"Tomson","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Institute of Clinical Sciences The University of Birmingham School of Dentistry Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udio Antonio Talge","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry Endodontic Division Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1111\/j.1600-9657.2009.00836.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1111\/j.1600-9657.2012.01125.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.5005\/jp-journals-10005-1427"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1111\/j.1600-9657.2011.01090.x"},{"key":"e_1_2_7_6_1","first-page":"457","article-title":"Knowledge of dentists on the management of tooth avulsion injuries in Rio de Janeiro","volume":"13","author":"Menezes MC","year":"2015","journal-title":"Brazil. 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