{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:09:32Z","timestamp":1769378972962,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["12\u20103495"],"award-info":[{"award-number":["12\u20103495"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aims<\/jats:title><jats:p>Pre\u2010transplant blood transfusions have previously shown a positive effect on organ allograft survival in humans and various animal species. The aims of this study were, first, to evaluate the effect of pre\u2010transplant donor\u2010specific blood transfusions on periodontal healing of fully developed allotransplanted teeth in monkeys; and second, to investigate the immune response against donor antigens and to determine a possible correlation between alloimmune reactions and histopathological signs of rejection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty monkeys (<jats:italic>Cercopithecus aethiops<\/jats:italic>) were divided into ten pairs with similar sizes of incisors. One monkey in each pair gave three transfusions to the other monkey with 1\u2010week intervals. One week after the last transfusion, each pair exchanged simultaneously a central maxillary incisor and a lateral mandibular incisor. The corresponding central maxillary and mandibular lateral incisors were autotransplanted to the contralateral sockets. All teeth were treated endodontically per\u2010operatively. Histocompatibility was evaluated by mixed lymphocyte culture before the first transfusion, while alloantibodies and cell\u2010mediated alloresponses were measured before transfusions and at 2 and 8\u00a0weeks after transplantation. All animals were sacrificed 8\u00a0weeks after tooth transplantation. Serial sections of the transplanted teeth were quantified histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mixed lymphocyte cultures showed positive reactions in 19 of 20 cases, indicating incompatibility. The majority of the monkeys developed antibodies towards the tooth donor. Cell\u2010mediated cytotoxicity was negative in all monkeys. Histoquantification revealed a mean score of 70% normal periodontal ligament (PDL) in autotransplanted teeth, with 5% ankylosis. The allografts had a mean score of 17% normal PDL and 63% ankylosis, with no significant influence of transfusion. However, in the mandibular grafts, a tendency towards a positive transfusion effect was seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Donor\u2010specific blood transfusion did not reduce ankylosis in tooth allografts. The healing of mandibular incisor tooth allografts was improved, but not that of maxillary incisors. Donor\u2010specific antibodies showed no effect on the survival of allograft PDL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/edt.12703","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T07:51:50Z","timestamp":1626076310000},"page":"20-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of donor\u2010specific blood transfusions on allotransplanted teeth in a monkey model: Histoquantification of periodontal healing"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4403-3475","authenticated-orcid":false,"given":"Ole","family":"Schwartz","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Rigshospitalet (University Hospital)  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mogens","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Blood Bank State Serum Institute  Copenhagen Denmark"},{"name":"CERPOP Inserm UPS Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebbe","family":"Dickmeiss","sequence":"additional","affiliation":[{"name":"Blood Bank State Serum Institute  Copenhagen Denmark"},{"name":"Department of Clinical Immunology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Ove","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Rigshospitalet (University Hospital)  Copenhagen 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