{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:45:05Z","timestamp":1768916705722,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C1C1006937"],"award-info":[{"award-number":["2020R1C1C1006937"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aim<\/jats:title>\n                    <jats:p>Frondoside A is a sea cucumber extract which is well known for its anti\u2010inflammatory and immunomodulatory properties. The purpose of this study was to evaluate the effect of Frondoside A application in the alveolar socket on inflammatory responses after delayed replantation in rat teeth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Human periodontal ligament cells were cultured and exposed to Frondoside A. Cell\u2010counting kit\u20108 assay was performed to evaluate the cell viability and nitric oxide assay was performed to assess the anti\u2010inflammatory effect of Frondoside A. Molars were extracted from 32 Sprague\u2013Dawley rats and randomly divided into control and Frondoside A groups. After 30\u2009min of extra\u2010oral dry time, molars were replanted. In the Frondoside A group, Frondoside A solution was applied in the alveolar socket before replantation. The animals were sacrificed after 28\u2009days and histologically and immunohistochemically evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      0.5\u2009\u03bcM Frondoside A showed higher cellular viability at 6\u2009h and lower production of nitric oxide compared with other Frondoside A solutions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). The Frondoside A group demonstrated lower inflammatory resorption scores in both middle 1\/3 and apical 1\/3 of root compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). The Frondoside A group showed lower levels of expression in both cathepsin K and CD45 compared with the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limits of this study, intra\u2010alveolar delivery of Frondoside A alleviates inflammatory root resorption in delayed replantation of rat teeth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/edt.12891","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T01:38:05Z","timestamp":1695260285000},"page":"178-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of intra\u2010alveolar delivery of Frondoside A on inflammatory response of delayed tooth replantation"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7401-8519","authenticated-orcid":false,"given":"Lan","family":"Herr","sequence":"first","affiliation":[{"name":"Department of Dentistry, Graduate School Kyung Hee University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-5566","authenticated-orcid":false,"given":"Ju Ri","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Kyung Hee University College of Dentistry, Kyung Hee Universtiy Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-2304","authenticated-orcid":false,"given":"Sang Wook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry Kyung Hee University  Seoul South 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