{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:56:07Z","timestamp":1790326567169,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aim<\/jats:title>\n                    <jats:p>Regenerative endodontic treatment is a promising approach for healing periapical lesions and continuous root maturation. Although previous studies have reported its outcomes, the dynamics of morphological changes over time remain unclear. Therefore, this study aimed to evaluate changes in the periapical status and root dimensions over a 60\u2010month follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The follow\u2010up duration, periapical status changes, calcific barrier formation, degree of apical closure and radiographic root area changes were compared with those of the last follow\u2010up in this retrospective study. Radiographic root area changes were calculated as the difference between the total root and total canal areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010eight patients (81 teeth) underwent regenerative endodontic treatment during the study period, of whom 32 patients (36 teeth, 62%) were included. The survival and success rates of the treated teeth were 100% and 94.4%, respectively. All teeth developed a calcific bridge in the cervical third of the root canal, indicating the presence of vital tissue. Apical narrowing (partial or total) was observed in 75% of the cases. The root maturation stage affected the percentage increase in the radiographic root area. Teeth in Cvek stages II\u2013III showed a higher radiographic root area increase than more mature teeth. All tooth radiographic root areas increased significantly in the initial 20\u2009months of the treatment and moderately thereafter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Regenerative endodontic treatment is a safe approach for traumatised immature teeth. The presence of a radiographic calcified bridge may be an early indication of treatment success. The main complete tooth morphological changes occur after approximately 20\u2009months posttreatment. These findings may help clinicians better understand the time\u2010dependent changes in the root morphology after treatment, improve the follow\u2010up schedule and predict the progress of healing during follow\u2010up visits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/edt.12986","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T07:33:31Z","timestamp":1729668811000},"page":"47-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Time\u2010Dependent Morphological Changes in Traumatic Immature Teeth With Necrotic Pulps Following Regenerative Endodontic Treatment: A Retrospective Study"],"prefix":"10.1111","volume":"41","author":[{"given":"Manal","family":"Maree","sequence":"first","affiliation":[{"name":"Endodontics Department, School of Dentistry Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omri","family":"Nabriski","sequence":"additional","affiliation":[{"name":"Endodontics Department, School of Dentistry Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-5369","authenticated-orcid":false,"given":"Margarita","family":"Yoshpe","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Hadassah Medical Center, Faculty of Dental Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-0157","authenticated-orcid":false,"given":"Shaul","family":"Lin","sequence":"additional","affiliation":[{"name":"Endodontics Department, School of Dentistry Rambam Health Care Campus  Haifa Israel"},{"name":"The Israeli National Center for Trauma &amp; Emergency Medicine Research, the Gertner Institute for Epidemiology 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