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The healing responses may get disturbed due to severe damage, loss of vascularity of the supporting structures, and infections. As a result, the prohealing mediators and pathways are overpowered by the destructive stimuli often manifested by an increased osteoclastic activity. Among the various late complications, the apical periodontitis or the periapical lesions are most worrisome for the patients and create clinical dilemma for the dentists. In the past, many such lesions were classified as cysts and subjected to surgical management. However, better understanding of lesion pathophysiology, three\u2010dimensional imaging, and molecular pathways have established their inflammatory nature. The advancements in materials such as calcium silicates, and regenerative techniques have propelled the research related to non\u2010surgical endodontic management as its clinical acceptability. The treatment largely follows the recommendations of regenerative medicine and is based on four principles: (a) establishing the drainage or an endodontic access to the area, (b) removal of most of the triggering agents such as necrosed pulp, toxins, and inflammatory mediators, (c) disinfection of the area, controlling inflammation and reversal of the acidic pH, and (d) maintenance of this infection\/inflammation\u2010free state for a long time through adequate sealing. This review aims to highlight the rationale of the approach, case selection, pathophysiology of the causation and healing, clinical protocols, and the limitations of non\u2010surgical endodontic management of large periapical lesions secondary to traumatic dental injuries.<\/jats:p>","DOI":"10.1111\/edt.13008","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T04:11:01Z","timestamp":1730520661000},"page":"43-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Non\u2010Surgical Endodontic Management of Large Periapical Lesions After Traumatic Dental Injuries"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-5110","authenticated-orcid":false,"given":"Nitesh","family":"Tewari","sequence":"first","affiliation":[{"name":"Division of Pediatric and Preventive Dentistry, Centre for Dental Education and Research All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amritha","family":"Rajeswary","sequence":"additional","affiliation":[{"name":"Division of Pediatric and Preventive Dentistry, Centre for Dental Education and Research All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-9241","authenticated-orcid":false,"given":"Alina","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Center of Pediatric Oral Health Research  Stockholm Sweden"},{"name":"Department of Endodontics Public Dental Health Services  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5361-5840","authenticated-orcid":false,"given":"Georgios","family":"Tsilingaridis","sequence":"additional","affiliation":[{"name":"Department of Endodontics Public Dental Health Services  Stockholm Sweden"},{"name":"Division of Paediatric Dentistry, Department of Dental Medicine Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2968174"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020434"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01510-6"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2002.00455.x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12395"},{"key":"e_1_2_13_7_1","first-page":"e429","article-title":"Occurrence and Timing of Complications Following Traumatic Dental Injuries: A Retrospective Study in a Dental Trauma Department","volume":"8","author":"Lin S.","year":"2016","journal-title":"Journal of Clinical and Experimental Dentistry"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(88)80054-2"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263X.1997.00046.x"},{"key":"e_1_2_13_10_1","unstructured":"\u201cAAE Consensus Conference Recommended Diagnostic Terminology \u201dhttps:\/\/www.aae.org\/specialty\/wp\u2010content\/uploads\/sites\/2\/2017\/07\/endodonticdiagnosisfall2013.pdf."},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12397"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500604"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.12.8738-8743.2005"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1986.tb00118.x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)80841-1"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80156-9"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031480"},{"key":"e_1_2_13_18_1","first-page":"203","volume-title":"Clinical Outline of Oral Pathology: Diagnosis and Treatment","author":"Eversole R. 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