{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T12:54:28Z","timestamp":1774097668878,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The latency to first pharmacological treatment (duration of untreated illness or \u2018<jats:styled-content style=\"fixed-case\">DUI<\/jats:styled-content>\u2019) is supposed to play a major role in terms of outcome in psychotic conditions. Interest in the field of affective disorders and, in particular, of duration of untreated anxiety, has been recently registered as well. However, a preliminary epidemiologic investigation of the phenomenon is necessary. The present study was aimed to investigate and compare age at onset, age at first pharmacological treatment and <jats:styled-content style=\"fixed-case\">DUI<\/jats:styled-content> in a sample of patients affected by different anxiety disorders. <jats:styled-content style=\"fixed-case\">DUI<\/jats:styled-content> was defined as the interval between the onset of the specific anxiety disorder and the administration of the first adequate pharmacological treatment in compliant subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study sample included 350 patients, of both sexes, with a <jats:styled-content style=\"fixed-case\">DSM\u2010IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TR<\/jats:styled-content> diagnosis of panic disorder (<jats:italic>n<\/jats:italic>\u2009=\u2009138), generalized anxiety disorder (<jats:italic>n<\/jats:italic>\u2009=\u2009127) and obsessive\u2013compulsive disorder (<jats:italic>n<\/jats:italic>\u2009=\u200985).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Panic disorder was associated with the shortest <jats:styled-content style=\"fixed-case\">DUI<\/jats:styled-content> (39.5 months), whereas obsessive\u2013compulsive disorder was associated with the longest latency to treatment (94.5 months) (<jats:italic>F<\/jats:italic>\u2009=\u200913.333; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Patients with generalized anxiety disorder showed a mean <jats:styled-content style=\"fixed-case\">DUI<\/jats:styled-content> of 81.6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Present results indicate that patients with different anxiety disorders may wait for years (from 3 up to 8) before receiving a first adequate pharmacological treatment. Differences in terms of age at onset, age at the first pharmacological treatment and, ultimately, in <jats:styled-content style=\"fixed-case\">DUI<\/jats:styled-content> in specific anxiety disorders may depend on multiple clinical and environmental factors. Latency to non\u2010pharmacological interventions (e.g. psychoeducation and different forms of psychotherapy) needs to be addressed and correlated with <jats:styled-content style=\"fixed-case\">DUI<\/jats:styled-content> in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12016","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T14:41:03Z","timestamp":1359038463000},"page":"374-380","source":"Crossref","is-referenced-by-count":57,"title":["Differences in latency to first pharmacological treatment (duration of untreated illness) in anxiety disorders: a study on patients with panic disorder, generalized anxiety disorder and obsessive\u2013compulsive disorder"],"prefix":"10.1111","volume":"7","author":[{"given":"Bernardo","family":"Dell'Osso","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Camuri","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Benatti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Buoli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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