{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:42:53Z","timestamp":1728175373193},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>It remains debatable whether early intervention for psychosis is capable of meeting the needs of at\u2010risk subjects. The aims of this study were to describe the actual impact of interventions on subjective difficulties and to explore the factors that may be associated with a poor outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were help\u2010seeking outpatients at a university hospital who met the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>riteria of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rodromal <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>yndromes. Changes in the symptoms, subjective experience and current insight were assessed using the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cales of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rodromal <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymptoms, the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ubjective <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ell\u2010being under <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>euroleptics, and the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale to <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssess <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nawareness of <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ental <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isorder, respectively. Global functioning, social functioning and subjective quality of life were evaluated using the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lobal <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment of <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>unctioning <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale, the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ocial <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>unctioning <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale, and the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uality of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ife 26, respectively. These measures were assessed both at baseline and after 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six patients agreed to participate. Of the 27 patients who completed the reassessment at the follow\u2010up point, 13 patients (48%) showed little improvement in their positive\/negative symptoms, subjective well\u2010being or awareness of their symptoms. Additionally, less severe negative symptoms, more severe general symptoms and lower subjective well\u2010being at baseline significantly predicted a deterioration of positive\/negative symptoms after 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that the current strategy for reducing psychosis risk based on positive symptoms should be reappraised.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12032","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T14:04:27Z","timestamp":1359036267000},"page":"24-31","source":"Crossref","is-referenced-by-count":14,"title":["Poor outcome associated with symptomatic deterioration among help\u2010seeking individuals at risk for psychosis: a naturalistic follow\u2010up study"],"prefix":"10.1111","volume":"8","author":[{"given":"Keiko","family":"Morita","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry School of Medicine Toho University  Tokyo 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