{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:29:36Z","timestamp":1770506976341,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Individuals with a diagnosis of schizophrenia have a reduced life expectancy compared with the general population and cardiovascular disease is the major contributor to this early mortality. The use of second\u2010generation antipsychotic (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) medications is associated with significant weight gain and metabolic side effects; however, there is limited knowledge in certain diagnostic groups, specifically early\u2010onset schizophrenia (<jats:styled-content style=\"fixed-case\">EOS<\/jats:styled-content>). This study aimed to investigate the metabolic side effects of <jats:styled-content style=\"fixed-case\">SGAs<\/jats:styled-content>, specifically olanzapine, risperidone and quetiapine, in a cohort of drug\u2010na\u00efve children and adolescents with first\u2010episode <jats:styled-content style=\"fixed-case\">EOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), serum cholesterol and triglycerides were measured at baseline and a median of 7\u2009months of follow up in drug\u2010na\u00efve children and adolescents with <jats:styled-content style=\"fixed-case\">EOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 49 children and adolescents received a diagnosis of first\u2010episode EOS and we had complete follow\u2010up data for 74% (N\u2009=\u200936). A significant increase in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, serum triglycerides and cholesterol was observed in the unselected cohort after commencement of <jats:styled-content style=\"fixed-case\">SGAs<\/jats:styled-content>. One\u2010third of children and adolescents had abnormal serum triglycerides and cholesterol; however, a dose\u2013response was not demonstrated. Olanzapine and quetiapine had a greater increase in serum triglycerides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>n addition to highlighting the need for routine screening for metabolic side effects in <jats:styled-content style=\"fixed-case\">EOS<\/jats:styled-content>, interventions to prevent and treat obesity and the metabolic syndrome are indicated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12083","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T04:09:08Z","timestamp":1377230948000},"page":"276-280","source":"Crossref","is-referenced-by-count":19,"title":["Metabolic changes in first\u2010episode early\u2010onset schizophrenia with second\u2010generation antipsychotics"],"prefix":"10.1111","volume":"8","author":[{"given":"Brian","family":"O'Donoghue","sequence":"first","affiliation":[{"name":"The Early Psychosis Prevention and Intervention Centre (EPPIC) Orygen Youth Health  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam R.","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Orygen Research Centre Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Paul","family":"Amminger","sequence":"additional","affiliation":[{"name":"Orygen Research Centre Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.02.007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2010.09.011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1549"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000220851.94392.30"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3283477a09"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08050756"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.1.145s"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00429-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2007.00271.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.205"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2004.01.014"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0607"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/11596300-000000000-00000"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2011.595370"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0812"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2011.00315.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.06.009"}],"container-title":["Early Intervention in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feip.12083","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.12083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:34:52Z","timestamp":1696296892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eip.12083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,22]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/eip.12083"],"URL":"https:\/\/doi.org\/10.1111\/eip.12083","archive":["Portico"],"relation":{},"ISSN":["1751-7885","1751-7893"],"issn-type":[{"value":"1751-7885","type":"print"},{"value":"1751-7893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,22]]}}}