{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:42:12Z","timestamp":1766086932018,"version":"3.40.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our case report addresses the use of clozapine in patients who have a history of quetiapine XR\u2010induced neutropenia. There are no current guidelines for this situation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present the case of a young woman treated with clozapine at a first\u2010episode psychosis clinic after a moderate quetiapine<jats:styled-content style=\"fixed-case\">XR<\/jats:styled-content>\u2010induced neutropenia (0,5\u20131,0\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\u2009L<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient was successfully treated with clozapine and lithium, with less psychotic symptoms and a better level of functioning. The neutrophil count remained normal during the treatment period, which has been longer than a year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The outcome of this case supports the notion that clinicians could consider introducing clozapine in treatment\u2010refractory patients who have a history of quetiapine<jats:styled-content style=\"fixed-case\">XR<\/jats:styled-content>\u2010induced neutropenia, with close blood monitoring. Lithium co\u2010administration may play a role in maintaining a normal neutrophil count.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12134","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T04:12:53Z","timestamp":1396411973000},"page":"151-155","source":"Crossref","is-referenced-by-count":9,"title":["Quetiapine<scp>XR<\/scp>\u2010induced neutropenia: is a clozapine trial still possible for treatment\u2010resistant schizophrenia? A case report"],"prefix":"10.1111","volume":"9","author":[{"given":"Gabrielle","family":"Cr\u00e9peau\u2010Gendron","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurosciences Laval University Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7849-5179","authenticated-orcid":false,"given":"Sophie","family":"L'Heureux","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences Laval University Qu\u00e9bec Qu\u00e9bec Canada"},{"name":"CHU de Qu\u00e9bec Qu\u00e9bec Qu\u00e9bec Canada"},{"name":"Institut Universitaire en Sant\u00e9 Mentale de Qu\u00e9bec Qu\u00e9bec Qu\u00e9bec 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