{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:26:27Z","timestamp":1786443987304,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Institutes Health Research Operating Grant","award":["102761"],"award-info":[{"award-number":["102761"]}]},{"name":"Master's Award","award":["245268"],"award-info":[{"award-number":["245268"]}]},{"name":"Nova Scotia Health Research Foundation Scotia Scholarship","award":["8652"],"award-info":[{"award-number":["8652"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Exposure to parental bipolar disorder (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) early in life may increase the risk of developing a mood disorder. However, the impact of early parent\u2013child relationships when a parent is affected and how this impacts an offspring's risk remains unclear. The primary objective of this study was to determine the association between parent\u2013child relationships and risk of mood disorder in offspring of parents with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and, secondly, to determine the interaction of temperament and life stress on this association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and thirty\u2010three offspring completed annual clinical assessments following <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>iddie <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chedule for <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ffective <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isorders (<jats:styled-content style=\"fixed-case\">KSADS<\/jats:styled-content>) format interviews as part of an ongoing <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>anadian prospective cohort study conducted from 1996 to 2013. Offspring completed measures of early adversity, life stress and temperament. Clinical data from the affected parents were prospectively collected over the first decade of their offspring's life using <jats:styled-content style=\"fixed-case\">SADS<\/jats:styled-content> format interviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher perceived neglect from mother and offspring emotionality were significantly associated with the hazard of mood disorder (hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>): 1.1, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.0\u20131.2 and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>: 1.7, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.0\u20133.1, respectively). Duration of exposure to parental <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> significantly interacted with offspring emotionality to predict mood disorder (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). Further, perceived neglect from mother was associated with offspring high emotionality (<jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neglect from mother is a significant early predictor of mood disorder in offspring at familial risk for <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and may increase emotional sensitivity. Psychosocial support and interventions for high\u2010risk families could be beneficial in reducing early adversity, maternal neglect and the risk of subsequent mood disorders in offspring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12195","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T12:05:51Z","timestamp":1414670751000},"page":"381-389","source":"Crossref","is-referenced-by-count":37,"title":["Early parent\u2013child relationships and risk of mood disorder in a <scp>C<\/scp>anadian sample of offspring of a parent with bipolar disorder: findings from a 16\u2010year prospective cohort study"],"prefix":"10.1111","volume":"10","author":[{"given":"Sarah","family":"Doucette","sequence":"first","affiliation":[{"name":"Department of Community Health and Epidemiology Dalhousie University  Halifax Nova Scotia 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