{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:44:20Z","timestamp":1788871460074,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NARSAD Young Investigator Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n It has been found that long\u2010chain omega\u20103 polyunsaturated fatty acids (\n PUFAs<\/jats:styled-content>\n ) reduce the risk of progression to first episode of psychosis (\n FEP<\/jats:styled-content>\n ) and may offer a safe and efficacious strategy for selective and indicated prevention in young people with ultra\u2010high\u2010risk (\n UHR<\/jats:styled-content>\n ) states. An opportunity for exploring the trajectory of\n FEP<\/jats:styled-content>\n and for investigating the efficacy of preventive treatments exists in 22q11.2 deletion syndrome (22q11\n DS<\/jats:styled-content>\n ), which has a 30% psychotic transition rate. The fact that 22q11\n DS<\/jats:styled-content>\n patients are more homogeneous than other\n UHR<\/jats:styled-content>\n groups and are characterized by high level of negative symptoms provides a strong rationale for the use of\n PUFAs<\/jats:styled-content>\n . The principal aim of the present trial is to investigate the effects of\n PUFAs<\/jats:styled-content>\n in individuals with 22q11\n DS<\/jats:styled-content>\n who are at\n UHR<\/jats:styled-content>\n for developing\n FEP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A prospective, randomized, double\u2010blind, placebo\u2010controlled, single\u2010centre study design will be used. Eighty individuals aged 12\u201326 will be randomly assigned to two treatment conditions.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The experimental group will receive\n PUFAs<\/jats:styled-content>\n . The placebo group will receive paraffin oil. Standard clinical assessments and neuropsychological tests will be performed at baseline and at 8\u2010, 12\u2010, 26\u2010 and 52\u2010week follow\u2010up. Blood samples will be collected at baseline and after 12 weeks. This study is registered as an\n I<\/jats:styled-content>\n nternational\n S<\/jats:styled-content>\n tandard\n RCT<\/jats:styled-content>\n , number 02070211. The corresponding author is supported by a\n NARSAD Y<\/jats:styled-content>\n oung\n I<\/jats:styled-content>\n nvestigator\n A<\/jats:styled-content>\n ward.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This is the protocol of a planned study that aims to test the efficacy of\n PUFAs<\/jats:styled-content>\n in the prodromal phase of\n FEP<\/jats:styled-content>\n , in a specific syndrome where there is strong evidence that a high genetic load is involved in the disorder.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/eip.12197","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T03:02:46Z","timestamp":1414119766000},"page":"390-396","source":"Crossref","is-referenced-by-count":7,"title":["Indicated prevention with long\u2010chain polyunsaturated omega\u20103 fatty acids in patients with 22q11\n DS<\/scp>\n genetically at high risk for psychosis. Protocol of a randomized, double\u2010blind, placebo\u2010controlled treatment trial"],"prefix":"10.1111","volume":"10","author":[{"given":"Marco","family":"Armando","sequence":"first","affiliation":[{"name":"Child and Adolescence Neuropsychiatry Unit Department of Neuroscience Bambino Ges\u00f9 Children's Hospital Rome Italy"},{"name":"School of Psychology University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"De Crescenzo","sequence":"additional","affiliation":[{"name":"Child and Adolescence Neuropsychiatry Unit Department of Neuroscience Bambino Ges\u00f9 Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Vicari","sequence":"additional","affiliation":[{"name":"Child and Adolescence Neuropsychiatry Unit Department of Neuroscience Bambino Ges\u00f9 Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Digilio","sequence":"additional","affiliation":[{"name":"Medical Genetic Unit Pediatric Department Bambino Ges\u00f9 Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pontillo","sequence":"additional","affiliation":[{"name":"Child and Adolescence Neuropsychiatry Unit Department of Neuroscience Bambino Ges\u00f9 Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Papaleo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Brain Technologies Istituto Italiano di Tecnologia Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Paul","family":"Amminger","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Medical University of Vienna Vienna Austria"},{"name":"Orygen Youth Health Research Centre Centre for Youth Mental Health University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09552"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2841"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90734-K"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.9.1580"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e3181b76683"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs060"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.04.020"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2010.09.007"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.07.026"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.192"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.187"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3115"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.10.921"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.185.4.291"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1614.2005.01714.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/13.2.261"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_5_19_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_5_20_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders, Research Version, Patient Edition","author":"First MB","year":"2002"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1987.tb10566.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.4.549"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867412450470"}],"container-title":["Early Intervention in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feip.12197","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.12197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:43:52Z","timestamp":1695498232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eip.12197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,24]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/eip.12197"],"URL":"https:\/\/doi.org\/10.1111\/eip.12197","archive":["Portico"],"relation":{},"ISSN":["1751-7885","1751-7893"],"issn-type":[{"value":"1751-7885","type":"print"},{"value":"1751-7893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,24]]}}}