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The study was conducted with the aim to evaluate the efficacy of ranitidine in olanzapine\u2010induced weight gain at two fixed doses of 150 and 300\u2009mg\u2009day<jats:sup>\u22121<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010five inpatients with an <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010\u2010<jats:styled-content style=\"fixed-case\">DCR<\/jats:styled-content> diagnosis of schizophrenia as their first episode were randomized into three groups of 25 patients each, receiving 150\u2009mg\u2009day<jats:sup>\u22121<\/jats:sup> ranitidine, 300\u2009mg\u2009day<jats:sup>\u22121<\/jats:sup> ranitidine and third group receiving only olanzapine. Their weight and body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) were measured at baseline and at intervals of 4 and 8 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were comparable with respect to their weight and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> at baseline. When a change in the weight and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was assessed at 4 and 8 weeks from baseline, no significant difference was observed between the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ranitidine at doses of 150 and 300\u2009mg\u2009day<jats:sup>\u22121<\/jats:sup> when combined with olanzapine was ineffective in attenuating olanzapine\u2010induced weight gain. The likely reasons could be the use of low doses for a shorter period of time, or mechanisms other than <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>2 receptors might play an important role in weight gain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12205","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T03:22:04Z","timestamp":1419218524000},"page":"522-527","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of ranitidine in olanzapine\u2010induced weight gain: a dose\u2013response study"],"prefix":"10.1111","volume":"10","author":[{"given":"Varun S.","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Psychiatry Central Institute of Psychiatry  Ranchi Jharkhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daya","family":"Ram","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Central Institute of Psychiatry  Ranchi Jharkhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051688"},{"key":"e_1_2_7_3_1","first-page":"7","article-title":"Adverse effects of atypical antipsychotics","volume":"62","author":"Wirshing DA","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2007.01.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.07.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbi032"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n1206"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1176\/ajp.156.11.1686","article-title":"Antipsychotic induced weight gain: a comprehensive research synthesis","volume":"156","author":"Allison DB","year":"1999","journal-title":"Am J Psychiatry"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36391"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6885.1091"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800721"},{"key":"e_1_2_7_12_1","first-page":"699","article-title":"Combination of diet, exercise and intermittent treatment of cimetidine on body weight and maintenance of weight loss. 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