{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T18:49:05Z","timestamp":1770576545037,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research (NIHR)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Discontinuation of antipsychotics following remission in first episode psychosis (<jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>) is a contentious area of practice. We aimed to investigate the views of early psychosis clinicians on this important clinical question.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed an 11 question online survey on medication discontinuation following remission of symptoms in <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>. The questionnaire was distributed to early intervention team workers in England and Wales via members of the National Early Psychosis Network who were requested to distribute it to their teams.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We received 172 questionnaire responses; 37% were nurses, 33% doctors, 11% psychologists and 19% were other allied health professionals. The average years of experience in psychiatry was 16.9. 75.4% of respondents thought that greater than 60% of patients would like to be considered for guided medication reduction\/discontinuation. Only 31.4% of respondents said that medication should be continued for over a year following remission. 61.4% of respondents felt that the quality of life of individuals was better in those who stop medication following remission. There was a significant difference in the response of professional groups to this question. 82.6% of respondents said they would be happy to support their patients in participating in a randomized trial of graded antipsychotic reduction\/discontinuation versus maintenance medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The views of clinicians regarding prophylactic antipsychotic medication following remission in <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content> are much less conservative than those in current guidelines; concern was expressed by many about the impact of antipsychotic medication on quality of life. A randomized trial of maintenance antipsychotic medication versus graded reduction\/discontinuation is feasible and has considerable clinician support.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12244","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T06:25:19Z","timestamp":1431411919000},"page":"355-361","source":"Crossref","is-referenced-by-count":31,"title":["Views of early psychosis clinicians on discontinuation of antipsychotic medication following symptom remission in first episode psychosis"],"prefix":"10.1111","volume":"10","author":[{"given":"Andrew","family":"Thompson","sequence":"first","affiliation":[{"name":"Division of Mental Health and Wellbeing Warwick Medical School University of Warwick  Coventry UK"},{"name":"Coventry and Warwickshire NHS Partnership Trust  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swaran","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Mental Health and Wellbeing Warwick Medical School University of Warwick  Coventry UK"},{"name":"Birmingham and Solihull Mental Health NHS Foundation Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Birchwood","sequence":"additional","affiliation":[{"name":"Division of Mental Health and Wellbeing Warwick Medical School University of Warwick  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"S13","article-title":"Prediction of outcome in first\u2010episode schizophrenia","volume":"54","author":"Lieberman JA","year":"1993","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1192\/S0007125000297699","article-title":"An analysis of the initial treatment phase in first episode psychosis","volume":"172","author":"Power P","year":"1998","journal-title":"B J Psychiatry"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2012.01883.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.3.241"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4024"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290010048009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.148.2.120"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60239-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbl015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.19"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.199"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2"},{"key":"e_1_2_7_14_1","first-page":"8","article-title":"Metabolic changes associated with antipsychotic use","volume":"6","author":"Lieberman JA","year":"2004","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"e_1_2_7_15_1","volume-title":"A Question of Choice","author":"Hogman G","year":"2001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(02)00030-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0114"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.02437.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.02.029"},{"key":"e_1_2_7_20_1","volume-title":"Australian Clinical Guidelines for Early Psychosis","author":"Early Psychosis Guidelines Writing Group","year":"2010"},{"key":"e_1_2_7_21_1","volume-title":"Psychosis and Schizophrenia in Adults: Treatment and Management. 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