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The strong preliminary results for the effectiveness of omega\u20103 polyunsaturated fatty acids (\n PUFA<\/jats:styled-content>\n s), coupled with the falling transition rate in ultra high\u2010risk (\n UHR<\/jats:styled-content>\n ) samples, mean that further study of such benign, potentially neuroprotective interventions is clinically and ethically required. Employing a multicentre approach, enabling a large sample size, this study will provide important information with regard to the use of omega\u20103\n PUFAs<\/jats:styled-content>\n in the\n UHR<\/jats:styled-content>\n group.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This trial is a 6\u2010month, double\u2010blind, randomized placebo\u2010controlled trial of 1.4 g day\n \u22121<\/jats:sup>\n omega\u20103\n PUFAs<\/jats:styled-content>\n in\n UHR<\/jats:styled-content>\n patients aged between 13 and 40 years. The primary hypothesis is that\n UHR<\/jats:styled-content>\n patients receiving omega\u20103\n PUFAs<\/jats:styled-content>\n plus cognitive\u2010behavioural case management (\n CBCM<\/jats:styled-content>\n ) will be less likely to transition to psychosis over a 6\u2010month period compared to treatment with placebo plus\n CBCM<\/jats:styled-content>\n . Secondary outcomes will examine symptomatic and functional changes, as well as examine if candidate risk factors predict response to omega\u20103\n PUFA<\/jats:styled-content>\n treatment in the\n UHR<\/jats:styled-content>\n group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This is the protocol of the\n NeuraproE<\/jats:styled-content>\n study. Utilizing a large sample, results from this study will be important in informing indicated prevention strategies for schizophrenia and other psychotic disorders, which may be the strongest avenue for reducing the burden, stigmatization, disability and economic consequences of these disorders.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/eip.12260","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T00:23:47Z","timestamp":1439771027000},"page":"418-428","source":"Crossref","is-referenced-by-count":57,"title":["NEURAPRO\u2010E study protocol: a multicentre randomized controlled trial of omega\u20103 fatty acids and cognitive\u2010behavioural case management for patients at ultra high risk of schizophrenia and other psychotic disorders"],"prefix":"10.1111","volume":"11","author":[{"given":"Connie","family":"Markulev","sequence":"first","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"McGorry","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnaby","family":"Nelson","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hok Pan","family":"Yuen","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison R.","family":"Yung","sequence":"additional","affiliation":[{"name":"Institute of Brain, Behaviour and Mental Health University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Mental Health and Wellbeing Warwick Medical School University of Warwick Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilufar","family":"Mossaheb","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Schl\u00f6gelhofer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Smesny","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Jena Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieuwe","family":"de Haan","sequence":"additional","affiliation":[{"name":"Academic Psychiatric Centre AMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Riecher\u2010R\u00f6ssler","sequence":"additional","affiliation":[{"name":"Psychiatric University Clinics University Psychiatric Outpatient Department Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"Nordentoft","sequence":"additional","affiliation":[{"name":"Department of Psychiatry E Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Yu Hai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapna","family":"Verma","sequence":"additional","affiliation":[{"name":"Early Psychosis Intervention Institute of Mental Health Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Hickie","sequence":"additional","affiliation":[{"name":"Brain & Mind Research Institute University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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