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Up to 30% of those with <jats:styled-content style=\"fixed-case\">22q11DS<\/jats:styled-content> develop schizophrenia during early adulthood. As cognitive decline has recently been found to predict onset of psychosis in adolescents with <jats:styled-content style=\"fixed-case\">22q11DS<\/jats:styled-content>, early interventions such as cognitive remediation (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) during adolescence are warranted. This paper investigates the durability of a remote, computerized, <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> programme for youth with <jats:styled-content style=\"fixed-case\">22q11DS<\/jats:styled-content>. Our aim was to determine if the positive effects of <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> persisted 6 months beyond intervention completion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A longitudinal design with 21 participants serving as their own controls was used. Youth were seen for neurocognitive assessments at pre\u2010treatment, after the targeted 8\u2010month intervention, at post\u2010treatment, and 6 months after for follow\u2010up. During the intervention, cognitive coaches met remotely with participants for <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> via video conferencing three times a week, and offered task\u2010specific strategies. To determine if intervention improvements held across the 6\u2010month follow\u2010up period, neurocognitive measures were statistically examined with repeated measures analysis of variances from pre\u2010treatment through follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> intervention proved durable. Post\u2010treatment improvements comprising cognitive flexibility, executive function, reaction time and working memory were maintained over the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results confirm previous research regarding the durability of <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> treatment and extend these findings to youth with <jats:styled-content style=\"fixed-case\">22q11DS<\/jats:styled-content>. The present study may serve to inform early intervention efforts focused on cognitive and functionally relevant rehabilitation goals for youth with <jats:styled-content style=\"fixed-case\">22q11DS<\/jats:styled-content> and suggests that <jats:styled-content style=\"fixed-case\">22q11DS<\/jats:styled-content> can potentially serve as a suitable model for examining the trajectory preceding psychosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12367","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T09:33:07Z","timestamp":1473931987000},"page":"686-693","source":"Crossref","is-referenced-by-count":11,"title":["Examining the durability of a hybrid, remote and computer\u2010based cognitive remediation intervention for adolescents with 22q11.2 deletion syndrome"],"prefix":"10.1111","volume":"12","author":[{"given":"Margaret A.","family":"Mariano","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences State University 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