{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:57:50Z","timestamp":1785239870171,"version":"3.55.0"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T00:00:00Z","timestamp":1496966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To explore the prevalence and clinicians\u2019 awareness of psychiatric comorbidities, and to identify factors associated with current psychiatric comorbidities in first\u2013episode schizophrenia (<jats:styled-content style=\"fixed-case\">FES<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this cross\u2013sectional study, 128 patients with <jats:styled-content style=\"fixed-case\">FES<\/jats:styled-content>, who were in symptomatic remission, were consecutively recruited from a local early intervention clinic. All patients were interviewed using the Chinese bilingual version of the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Axis I Disorders, Positive and Negative Syndrome Scales, Scale to Assess Unawareness of Mental Disorder, Social and Occupational Functioning Assessment Scale, Simpson\u2013Angus Scale, Barnes Akathisia Rating Scale and Abnormal Involuntary Movement Scale. Bivariate and multivariate analyses were performed to investigate factors associated with psychiatric comorbidities in <jats:styled-content style=\"fixed-case\">FES<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lifetime and point prevalence of psychiatric comorbidities among <jats:styled-content style=\"fixed-case\">FES<\/jats:styled-content> patients were 47.7% and 27.3%, respectively. Current psychiatric comorbidities were documented on the medical records of 39.3% of the patients. The <jats:styled-content style=\"fixed-case\">FES<\/jats:styled-content> patients with current psychiatric comorbidities had a lower level of functioning. Depression in <jats:styled-content style=\"fixed-case\">FES<\/jats:styled-content> was also associated with akathisia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Psychiatric comorbidities are prevalent among community <jats:styled-content style=\"fixed-case\">FES<\/jats:styled-content> patients. In addition to achieving symptomatic remission in schizophrenia, both treating psychiatric comorbidities and minimizing the side\u2013effects of treatment, particularly akathisia, are fundamental for supporting <jats:styled-content style=\"fixed-case\">FES<\/jats:styled-content> patients in their journey to recovery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12426","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T08:25:08Z","timestamp":1542702308000},"page":"1128-1136","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and clinicians\u2019 awareness of psychiatric comorbidities among first\u2013episode schizophrenia"],"prefix":"10.1111","volume":"12","author":[{"given":"Man\u2013wah","family":"Siu","sequence":"first","affiliation":[{"name":"Department of Psychiatry Kwai Chung Hospital, Hong Kong SAR  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Shiu\u2013yin","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kwai Chung Hospital, Hong Kong SAR  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Tak\u2013lam","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kwai Chung Hospital, Hong Kong SAR  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2010.515205"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp148"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.01.012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.184.4.346"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950100074007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.3.441"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.154.5.672"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00205-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033472"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700028488"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/hrp.8.1.18"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2000.90063.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790210065008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2004.09.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn135"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v59n0204"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.10.016"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.09.037"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820140051005"},{"key":"e_1_2_7_21_1","article-title":"Predictors of functioning in people suffering from first\u2013episode psychosis 1 year into entering early intervention service in Hong Kong","author":"Chong C. S. Y.","year":"2016","journal-title":"Early Intervention in Psychiatry"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.08.018"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001504-200101000-00004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.07.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0027649"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(02)00014-X"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2003.08.001"},{"key":"e_1_2_7_29_1","first-page":"534","volume-title":"ECDEU assessment manual for psychopharmacology","author":"Guy W.","year":"1976"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370505000904"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr077"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.559271"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.325"},{"key":"e_1_2_7_34_1","volume-title":"General Psychopathology","author":"Jaspers K.","year":"1976"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/13.2.261"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.150.11.1643"},{"key":"e_1_2_7_37_1","volume-title":"The Hong Kong mental morbidity survey 2010. Health and medical research Fund","author":"Lam L.","year":"2014"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1300\/J070v13n02_02"},{"key":"e_1_2_7_39_1","first-page":"1","volume-title":"Clinical practice and epidemiology in mental health","author":"Mauri M.","year":"2006"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881103017001713"},{"issue":"3","key":"e_1_2_7_41_1","first-page":"172","article-title":"The relationships between depression and remission in first\u2013episode psychosis","volume":"5","author":"Oosthuizen P.","year":"2006","journal-title":"World Psychiatry"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.1.53"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2011.03.004"},{"issue":"12","key":"e_1_2_7_44_1","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1176\/ajp.156.12.1998","article-title":"Obsessive\u2013compulsive disorder in patients with first\u2013episode schizophrenia","volume":"156","author":"Poyurovsky M.","year":"1999","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(01)00238-4"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200418140-00004"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0790966700000860"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033362"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.947"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3182677958"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.06.008"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-690X.2004.00196.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1970.tb02066.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.9.1379"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950020033003"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800180043008"},{"issue":"1","key":"e_1_2_7_57_1","first-page":"7","article-title":"The Chinese\u2013bilingual SCID\u2013I\/P project: Stage 1\u2013reliability for mood disorders and schizophrenia","volume":"13","author":"So E.","year":"2003","journal-title":"Hong Kong Journal of Psychiatry"},{"issue":"1","key":"e_1_2_7_58_1","first-page":"19","article-title":"The Chinese bilingual SCIDI\/P project: Stage 2\u2014reliability for anxiety disorders, adjustment disorders and \u2018no diagnosis\u2019","volume":"13","author":"So E.","year":"2003","journal-title":"Hong Kong Journal of Psychiatry"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-440X(95)90104-3"},{"key":"e_1_2_7_60_1","first-page":"182","article-title":"Comorbidity in psychosis at first hospitalization","volume":"40","author":"Strakowski S. M.","year":"1993","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.10.033"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-70990-1_7"},{"key":"e_1_2_7_63_1","volume-title":"Prescribing guidelines in psychiatry","author":"Taylor D.","year":"2012"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00049-9"},{"issue":"2","key":"e_1_2_7_65_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1176\/ajp.156.2.315","article-title":"Prevalence of depressive symptoms early in the course of schizophrenia","volume":"156","author":"Wassink T. H.","year":"1999","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0607"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-440X(99)90001-9"},{"issue":"11","key":"e_1_2_7_68_1","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1176\/ajp.156.11.1736","article-title":"Depressive symptoms in schizophrenia","volume":"156","author":"Zisook S.","year":"1999","journal-title":"American Journal of Psychiatry"}],"container-title":["Early Intervention in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feip.12426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.12426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:57:27Z","timestamp":1694757447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eip.12426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,9]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/eip.12426"],"URL":"https:\/\/doi.org\/10.1111\/eip.12426","archive":["Portico"],"relation":{},"ISSN":["1751-7885","1751-7893"],"issn-type":[{"value":"1751-7885","type":"print"},{"value":"1751-7893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,9]]}}}