{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:45Z","timestamp":1787014125909,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Chinese National Science Foundation","doi-asserted-by":"crossref","award":["81571333"],"award-info":[{"award-number":["81571333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chinese National key Research and Development Program","award":["2016YFC0906302"],"award-info":[{"award-number":["2016YFC0906302"]}]},{"name":"Guangdong Science and Technology Major Program","award":["2016B010108003"],"award-info":[{"award-number":["2016B010108003"]}]},{"name":"Guangdong Provincial Medical Science Research Fund","award":["A2015475"],"award-info":[{"award-number":["A2015475"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,2]]},"abstract":"\n Background<\/jats:title>\n \n The effect of penicillin therapy on clinical outcomes vary among patients with general paresis (\n GP<\/jats:styled-content>\n ). We sought to explore biomarkers that might serve as predictors of clinical outcomes in\n GP<\/jats:styled-content>\n and identify patients requiring early intervention.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thirty\u2010five inpatients with\n GP<\/jats:styled-content>\n were recruited. Each\n GP<\/jats:styled-content>\n patient underwent comprehensive neuropsychological, neuroimaging and laboratory assessments before receiving penicillin therapy, and returned for follow\u2010up evaluations after 6 months. The visual rating of medial temporal lobe atrophy (\n MTA<\/jats:styled-content>\n ) and the Fazekas scale was used to analyze the neuroimaging abnormalities.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n MTA<\/jats:styled-content>\n scores were correlated with the pre\u2010treatment cognitive scores and change in Mini Mental State Examination scores.\n GP<\/jats:styled-content>\n patients with a Clinical Dementia Rating Scale (\n CDR<\/jats:styled-content>\n ) \u22641 or\n MTA<\/jats:styled-content>\n scores \u22642 achieved significant improvement in neuropsychological test scores, as compared with patients with\n CDR<\/jats:styled-content>\n >1 or\n MTA<\/jats:styled-content>\n scores >2. Fazekas scale scores correlated with the pre\u2010treatment attention scores. Significant improvements in cognitive test scores were observed in\n GP<\/jats:styled-content>\n patients with normalization of serum rapid plasma regain (\n RPR<\/jats:styled-content>\n ) titers, but not those without normalization of\n RPR<\/jats:styled-content>\n titers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Severe\n MTA<\/jats:styled-content>\n may serve as a predictor of poor cognitive outcome and an indicator of severe cognitive impairment in\n GP<\/jats:styled-content>\n patients. Thus, early interventions for improving cognitive function may be considered for\n GP<\/jats:styled-content>\n patients with severe\n MTA<\/jats:styled-content>\n . White matter hyperintensities may associated with attention impairment. Serum\n RPR<\/jats:styled-content>\n titer may serve as a sensitive indicator of therapeutic effect in\n GP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/eip.12441","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T15:18:34Z","timestamp":1491405514000},"page":"30-38","source":"Crossref","is-referenced-by-count":15,"title":["Medial temporal lobe atrophy as a predictor of poor cognitive outcomes in general paresis"],"prefix":"10.1111","volume":"13","author":[{"given":"Ben","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) and Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haishan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Guangzhou Medical University, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinni","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yuping","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) and Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000126041.99024.86"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.02.021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.121146"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.351"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2010.00183.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0380-z"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1959.02340170023003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.484"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6252-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12.2.246"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.1.1"},{"key":"e_1_2_8_16_1","first-page":"179","article-title":"Assessment of older people: Self\u2010maintaining and instrumental activities of daily living","volume":"9","author":"Lawton M. P.","year":"1969","journal-title":"Materials Science Forum"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.427"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12680"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/591534"},{"key":"e_1_2_8_20_1","first-page":"448","article-title":"The Alzheimer's disease assessment scale: An instrument for assessing treatment efficacy","volume":"19","author":"Mohs R. C.","year":"1983","journal-title":"Psychopharmacology Bulletin"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2014.10.008"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1258\/095646204322764253"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.09.009"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.58.110405.085516"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13571"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-8343(95)00030-U"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00060-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.10.967"},{"key":"e_1_2_8_29_1","first-page":"e14","article-title":"Progressive dementia and mesiotemporal atrophy on brain MRI: Neurosyphilis mimicking pre\u2010senile Alzheimer's disease?","volume":"15","author":"Van E. P.","year":"2008","journal-title":"European Journal of Neurology"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326908"},{"key":"e_1_2_8_31_1","first-page":"1","article-title":"Clinical and neuropsychological characteristics of general paresis misdiagnosed as primary psychiatric disease","volume":"16","author":"Wang Y.","year":"2016","journal-title":"BMC Psychiatry"},{"key":"e_1_2_8_32_1","first-page":"231","article-title":"The cognitive subscale of Alzheimer's Disease Assessment Scale, Chinese version in staging of Alzheimer disease","volume":"18","author":"Wang H.","year":"2004","journal-title":"Alzheimer Disease and Associated Disorders"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)92674-3"},{"issue":"12","key":"e_1_2_8_34_1","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2010. Mmwr.recommendations & Reports Morbidity & Mortality Weekly Report","volume":"59","author":"Workowski K. A.","year":"2010","journal-title":"recommendations & Reports"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.08.019"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2002.00930.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.23.3.jnp300"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055328"}],"container-title":["Early Intervention in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feip.12441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.12441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T01:47:32Z","timestamp":1694656052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eip.12441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,5]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/eip.12441"],"URL":"https:\/\/doi.org\/10.1111\/eip.12441","archive":["Portico"],"relation":{},"ISSN":["1751-7885","1751-7893"],"issn-type":[{"value":"1751-7885","type":"print"},{"value":"1751-7893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,5]]}}}