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An unbalanced immune response and a pro\u2010inflammatory state might underlie this process. In treated patients, abnormal white blood cell (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>), lymphocyte and neutrophil count suggests atypical immune response related to clinical variables. We aimed to test the hypothesis that newly diagnosed na\u00efve patients with non\u2010affective psychosis would show abnormal blood cell count values after controlling for potential confounding factors compared to matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010five patients were compared with 80 controls matched for age, gender, body mass index and smoking. Analyses were conducted before and after controlling for smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients and controls displayed similar mean values (\u00d710<jats:sup>3<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">\u03bcL<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>]) for <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> count 7.02 [2.2] vs 6.50 [1.7] (<jats:italic>P<\/jats:italic> = .159), neutrophil count 4.25 [1.8] vs 3.84 [1.3] (<jats:italic>P<\/jats:italic> = .110) and monocyte count 0.43 [0.2] vs 0.40 [0.1] (<jats:italic>P<\/jats:italic> = .326). After controlling for smoking, 38 non\u2010smoking patients showed a higher <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> and neutrophil count compared with 49 matched controls. Respective means of 7.01 [2.2] vs 5.97 [1.4] (<jats:italic>P<\/jats:italic> = .011) for <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> and 4.24 [1.9] vs 3.51 [1.2] (<jats:italic>P<\/jats:italic> = .028) for neutrophil count. Monocyte count showed an increased mean value 0.43 [0.2] vs 0.36 [0.1] with a trend towards signification (<jats:italic>P<\/jats:italic> = .063).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that abnormal immune response is present before the effects of medication and other confounders had taken place. Increased immune parameters might underlie the high ratio of medical co\u2010morbidities described in schizophrenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12456","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T10:06:38Z","timestamp":1502186798000},"page":"95-100","source":"Crossref","is-referenced-by-count":34,"title":["Blood cell count in antipsychotic\u2010naive patients with non\u2010affective psychosis"],"prefix":"10.1111","volume":"13","author":[{"given":"Clemente","family":"Garcia\u2010Rizo","sequence":"first","affiliation":[{"name":"Barcelona Clinic Schizophrenia Unit, Neuroscience Institute Hospital Clinic  Barcelona Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS)  Barcelona Spain"},{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Casanovas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Vall d'Hebron University Hospital, Autonomous University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Fernandez\u2010Egea","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM)  Madrid Spain"},{"name":"Department of Psychiatry University of Cambridge, Addenbrooke's Hospital  Cambridge UK"},{"name":"Cambridgeshire and Peterborough NHS Foundation Trust  Huntingdon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Barcelona Clinic Schizophrenia Unit, Neuroscience Institute Hospital Clinic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Meseguer","sequence":"additional","affiliation":[{"name":"Barcelona Clinic Schizophrenia Unit, Neuroscience Institute Hospital Clinic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibiana","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Barcelona Clinic Schizophrenia Unit, Neuroscience Institute Hospital Clinic  Barcelona Spain"},{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Mezquida","sequence":"additional","affiliation":[{"name":"Barcelona Clinic Schizophrenia Unit, Neuroscience Institute Hospital Clinic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Bioque","sequence":"additional","affiliation":[{"name":"Barcelona Clinic Schizophrenia Unit, Neuroscience Institute Hospital Clinic  Barcelona Spain"},{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Nevada School of Medicine  Reno Nevada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Barcelona Clinic Schizophrenia Unit, Neuroscience Institute Hospital Clinic  Barcelona Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS)  Barcelona Spain"},{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM)  Madrid Spain"},{"name":"Department of Medicine University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.08.015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2015.1017464"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1599-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","unstructured":"Cabrera B. 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