{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:36:53Z","timestamp":1780375013305,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Federal Ministry for Education and Research","award":["01 GI 9935"],"award-info":[{"award-number":["01 GI 9935"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Psychological interventions, such as cognitive behavioural therapy (<jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>) and supportive counselling (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>), are used to treat people with schizophrenia and people at clinical high risk (<jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content>) of psychosis. However, little information is available on predictors of treatment response. This study aims to identify such predictors of psychological interventions in <jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 128 help\u2010seeking <jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content> outpatients were randomized into two groups\u2014integrated psychological intervention (<jats:styled-content style=\"fixed-case\">IPI<\/jats:styled-content>), including <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>\u2014for 12 months. Multiple regression analysis was used to identify demographic, symptomatic and functional variables that predict improvement in positive (<jats:styled-content style=\"fixed-case\">PANSS<\/jats:styled-content> Positive), negative (<jats:styled-content style=\"fixed-case\">PANSS<\/jats:styled-content> Negative) and basic symptoms (Basic symptom total score) and improvement in functioning (<jats:styled-content style=\"fixed-case\">GAF<\/jats:styled-content>) at 1\u2010year follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the merged group (<jats:styled-content style=\"fixed-case\">IPI<\/jats:styled-content> + <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>), people who lived independently, were younger and presented with higher baseline functioning showed more improvement in symptomatic outcomes at follow up. Negative symptoms at baseline predicted less improvement in positive and basic symptoms. Being married or cohabiting and living in the primary family were found to correlate with good functioning at 1\u2010year follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Younger <jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content> individuals and those who are functioning well may particularly benefit from early intervention. Treatment might need to be modified for low\u2010functioning <jats:styled-content style=\"fixed-case\">CHR<\/jats:styled-content> and those who already display higher scores of negative symptoms.<\/jats:p><jats:p>Registration number: <jats:styled-content style=\"fixed-case\">NCT00204087<\/jats:styled-content>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12460","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T15:08:29Z","timestamp":1499180909000},"page":"120-127","source":"Crossref","is-referenced-by-count":9,"title":["Predictors of treatment response to psychological interventions in people at clinical high risk of first\u2010episode psychosis"],"prefix":"10.1111","volume":"13","author":[{"given":"Helen","family":"Wessels","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Kuhr","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics, Informatics and Epidemiology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Berning","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"P\u00fctzfeld","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Bottlender","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Klinikum L\u00fcdenscheid  L\u00fcdenscheid Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Maurer","sequence":"additional","affiliation":[{"name":"Central Institute of Mental Health  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010J\u00fcrgen","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Ludwig Maximilians University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Gaebel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"H\u00e4fner","sequence":"additional","affiliation":[{"name":"Central Institute of Mental Health  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Klosterk\u00f6tter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bechdolf","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Cologne  Cologne Germany"},{"name":"Department of Psychiatry, Psychotherapy and Psychosomatic Medicine Vivantes Klinikum am Urban  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.08.011"},{"key":"e_1_2_6_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000127692.23278.a9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.109.066357"},{"key":"e_1_2_6_6_1","unstructured":"Bechdolf A. 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