{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:56:12Z","timestamp":1783734972813,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:00:00Z","timestamp":1501804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH093676"],"award-info":[{"award-number":["MH093676"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Despite the considerable public health impact of bipolar disorder (BD), no psychosocial interventions have been systematically evaluated in its early prodromal stages. We describe the rationale, design and analytic methods for a 3\u2010site randomized trial of family\u2010focused treatment for youth at high risk (FFT\u2010HR) for BD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants (ages 9\u201017\u2009years) have a diagnosis of unspecified BD or major depressive disorder, current mood symptoms and at least one first\u2010 or second\u2010degree relative with a lifetime history of BD I or II. Participants are randomly assigned to FFT\u2010HR (12 sessions in 4\u2009months of family psychoeducation and skills training) or enhanced care (EC; 6 individual and family sessions over 4\u2009months), with pharmacotherapy provided as needed. A subset of participants undergo pre\u2010 and post\u2010treatment functional MRI (fMRI) scans while performing face\u2010rating and family problem\u2010solving tasks designed to activate corticolimbic circuitry. Independent evaluators assess participants\u2019 status every 4 to 6\u2009months for up to 4\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We hypothesize that FFT\u2010HR will be more effective than EC in reducing the severity of mood symptoms (primary outcome) and the hazard of a first manic episode (secondary) over 4\u2009years. Secondarily, we will explore whether FFT\u2010HR is associated with greater decreases in amygdala activation and increases in dorsolateral, ventrolateral or anterior medial prefrontal cortex activation from pre\u2010 to post\u2010treatment. Clinical characteristics of 133 subjects enrolled at baseline are described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study will test a novel intervention to reduce the early symptoms of BD, and identify neural and behavioural mechanisms that may help refine future treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12463","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T11:35:25Z","timestamp":1501846525000},"page":"208-216","source":"Crossref","is-referenced-by-count":22,"title":["Early intervention for youth at high risk for bipolar disorder: A multisite randomized trial of family\u2010focused treatment"],"prefix":"10.1111","volume":"13","author":[{"given":"David J.","family":"Miklowitz","sequence":"first","affiliation":[{"name":"Los Angeles (UCLA) Semel Institute University of California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Schneck","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Colorado Denver School of Medicine  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia D.","family":"Walshaw","sequence":"additional","affiliation":[{"name":"Los Angeles (UCLA) Semel Institute University of California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Garrett","sequence":"additional","affiliation":[{"name":"Psychiatry and Behavioral Sciences Stanford University School of Medicine  Stanford California"},{"name":"Department of Psychiatry University of Texas Health Science Center  San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manpreet K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Psychiatry and Behavioral Sciences Stanford University School of Medicine  Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Sugar","sequence":"additional","affiliation":[{"name":"Los Angeles (UCLA) Semel Institute University of California  Los Angeles California"},{"name":"Department of Biostatistics, UCLA Fielding School of Public Health  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiki D.","family":"Chang","sequence":"additional","affiliation":[{"name":"Psychiatry and Behavioral Sciences Stanford University School of Medicine  Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_6_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14010035"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.07.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530497"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08101569"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13121577"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2008.100"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790300064008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.126706"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00260.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.09.007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2012.06.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23572"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15040414"},{"key":"e_1_2_6_17_1","first-page":"313","article-title":"Medial cortex activity, self\u2010reflection and depression","volume":"4","author":"Johnson M. 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