{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:34:38Z","timestamp":1779928478714,"version":"3.53.1"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Center of Competence in Research (NCCR) \u201cSYNAPSY - The Synaptic Bases of Mental Diseases\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The objective of this study is to explore, within a sample of early psychosis patients (EPP), if subgroups regarding rate of violent behaviour (VB) against others can be identified on the basis of dynamic risk factors (treatment modifiable characteristics).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a sample of 265 EPP, treated at the Treatment and Early Intervention in Psychosis Program in Lausanne, we conducted a latent\u2010class analysis on the basis of the main dynamic VB risk factors (substance use disorder [SUD], positive symptoms, insight, and impulsivity). VB were restricted to \u201cserious violence\u201d and were assessed through patients self\u2010report, interview with relatives or forensic services and with a standardized instrument.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis confirmed the heterogeneity of the sample regarding rate of VB. Patients could be stratified within 4 subgroups, 3 of which were at increased risk of VB. The two groups with the highest rates of VB displayed specific clinical profiles. The first one was characterized by high levels of impulsivity, hostility, positive symptoms and SUD, and the second, by low level of insight and low social functioning. These patterns suggest that significant difficulties in social interaction may contribute to the emergence of aggressive reactions against others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Identification of EPP at increased risk of VB seems possible on the basis of dynamic risk factors. If confirmed prospectively, this could pave the way to the development of preventive strategies and specific interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12512","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T04:16:44Z","timestamp":1510805804000},"page":"517-524","source":"Crossref","is-referenced-by-count":22,"title":["Violent behaviour in early psychosis patients: Can we identify clinical risk profiles?"],"prefix":"10.1111","volume":"13","author":[{"given":"Valerie","family":"Moulin","sequence":"first","affiliation":[{"name":"Unit for Research in Legal Psychiatry and Psychology, Institute of Forensic Psychiatry, Department of Psychiatry Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Palix","sequence":"additional","affiliation":[{"name":"Unit for Research in Legal Psychiatry and Psychology, Institute of Forensic Psychiatry, Department of Psychiatry Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2273-6241","authenticated-orcid":false,"given":"Philippe","family":"Golay","sequence":"additional","affiliation":[{"name":"Service of General Psychiatry, Department of Psychiatry Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Dumais","sequence":"additional","affiliation":[{"name":"Institut Philippe\u2010Pinel de Montr\u00e9al and Department of Psychiatry, Faculty of Medicine University of Montr\u00e9al  Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mehdi","family":"Gholamrezaee","sequence":"additional","affiliation":[{"name":"Centre for Psychiatric Epidemiology and Psychopathology, Department of Psychiatry Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Azzola","sequence":"additional","affiliation":[{"name":"Unit for Research in Legal Psychiatry and Psychology, Institute of Forensic Psychiatry, Department of Psychiatry Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp S.","family":"Baumann","sequence":"additional","affiliation":[{"name":"Service of General Psychiatry, Department of Psychiatry Lausanne University Hospital (CHUV)  Lausanne Switzerland"},{"name":"Center for Psychiatric Neuroscience Department of Psychiatry, Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Alameda","sequence":"additional","affiliation":[{"name":"Service of General Psychiatry, Department of Psychiatry Lausanne University Hospital (CHUV)  Lausanne Switzerland"},{"name":"Center for Psychiatric 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