{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:15:42Z","timestamp":1767651342923},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Early clinical response predicts symptomatic remission and recovery in the maintenance treatment phase of first\u2010episode schizophrenia (FES). However, little is known about predictors of symptomatic remission during acute treatment of severely ill patients with FES. Here, we conducted a secondary analysis of our retrospective observational study, which examined response, remission and treatment\u2010resistance rates in seriously ill patients with FES spectrum disorders involuntarily hospitalized and treated with algorithm\u2010based pharmacotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review of 131 involuntarily admitted patients with schizophrenia or schizoaffective disorder. Our algorithm aimed to delay olanzapine treatment, standardize medications and suggest initiation of clozapine after failure of third\u2010line antipsychotic treatment. The duration of each adequate antipsychotic treatment at an optimal dosage was 4 weeks or more. Remission was defined using the symptom\u2010severity component of consensus remission criteria. A logistic regression model was applied to identify significant predictors of remission at discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 74 patients (56%) were in remission at discharge. Non\u2010remitters were hampered from becoming remitters mainly by the presence of negative symptoms. There were no differences in first\u2010line antipsychotics, dosage of antipsychotics at time of response and adherence rates to algorithm\u2010based pharmacotherapy between remitters and non\u2010remitters. Shorter duration of untreated psychosis, favourable early response and less negative symptoms at baseline were identified as independent predictors of remission at discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The importance of early intervention and specific and adequate treatments of negative symptoms is highlighted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12531","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T10:08:43Z","timestamp":1513073323000},"page":"589-597","source":"Crossref","is-referenced-by-count":5,"title":["Predictors of remission during acute treatment of first\u2010episode schizophrenia patients involuntarily hospitalized and treated with algorithm\u2010based pharmacotherapy: Secondary analysis of an observational study"],"prefix":"10.1111","volume":"13","author":[{"given":"Bunta","family":"Yoshimura","sequence":"first","affiliation":[{"name":"Department of Psychiatry Okayama 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