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To better understand high\u2010risk girls\u2019 mental health, we assessed: (1) psychotic\u2010spectrum symptoms; (2) cumulative trauma, adversity and loss exposures (C\u2010TALE) and adversity\u2010indicators (symptoms, maladaptive coping, stressor\u2010reactivity); and SAU risk\u2010factors; and (3) relationships among psychotic\u2010spectrum symptoms, adversity\u2010indicators and SAU risk\u2010factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We administered the Structured Clinical Interviews for Psychotic Spectrum, and Trauma and Loss Spectrum to 158 adolescent delinquent girls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Girls\u2019 psychotic\u2010spectrum profiles were similar to previously reported adult psychotic patients and characterized by typical symptoms (hallucinations\/delusions, reported largely SAU\u2010independent), interpersonal sensitivity, schizoid traits and paranoia (over\u2010interpretation, anger over\u2010reactivity, hypervigilance). Auditory\/visual hallucinations (55.7%), delusions (92.4%), ideas of reference (96.8%) and adversity (90.0% \u226510\/24 C\u2010TALE\u2010types) were common. Mean loss (4) and trauma (8) onset\u2010age occurred before SAU\u2010onset (12). Significant positive correlations were found among psychotic\u2010spectrum symptoms, stressor\u2010reactivity, C\u2010TALE, adversity\u2010indicators; and number of SAU\u2010types; and a negative correlation occurred between psychotic\u2010spectrum symptoms and earlier alcohol use onset. After controlling for number of SAU\u2010types, stressor\u2010reactivity and adversity\u2010related numbing individually had the largest associations with total psychotic\u2010spectrum symptoms (<jats:italic>b<\/jats:italic>\u2009=\u20092.6\u20104.3). Girls averaged more than 4 maladaptive coping strategies (e.g., 24.8% attempted suicide) <jats:italic>in response to adversity<\/jats:italic>, amplifying potential health\u2010disparities. No racial\/ethnic differences emerged on psychotic\u2010spectrum symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This symptom constellation during adolescence likely interferes with social and academic functioning. Whether representing a prodromal phase, trauma\u2010response or cross\u2010diagnostic psychopathology, accurate early detection and appropriate treatment of psychotic\u2010spectrum symptoms are warranted to improve functional outcomes in vulnerable populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12533","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T09:03:03Z","timestamp":1514451783000},"page":"74-86","source":"Crossref","is-referenced-by-count":5,"title":["Psychotic\u2010spectrum symptoms, cumulative adversity exposure and substance use among high\u2010risk girls"],"prefix":"10.1111","volume":"12","author":[{"given":"Amy E.","family":"Lansing","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California, San Diego  La Jolla California"},{"name":"Department of Sociology San Diego State University  San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy Y.","family":"Plante","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California, San Diego  La Jolla California"},{"name":"Department of Sociology San Diego State University  San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Fennema\u2010Notestine","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California, San Diego  La Jolla California"},{"name":"Department of Radiology University of California, San Diego  La Jolla California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh","family":"Golshan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California, San Diego  La Jolla California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey N.","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Sociology San Diego State University  San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1\u201313","article-title":"PTSD, trauma, and comorbid psychiatric disorders in detained youth","volume":"1","author":"Abram K. 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