{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:43:01Z","timestamp":1791571381007,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The primary aim of this study was to examine the effect of recent tobacco, alcohol and cannabis use on treatment outcomes among participants experiencing first episode psychosis (FEP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Secondary data analyses were conducted on 404 participants enrolled in the Recovery After an Initial Schizophrenia Episode\u2014Early Treatment Program (RAISE\u2010ETP) study. RAISE\u2010ETP investigated the effectiveness of a coordinated specialty care (CSC) intervention for FEP in community mental health agencies in the United States. Generalized estimating equations were used to examine whether recent tobacco smoking, alcohol, and cannabis use at baseline were associated with illness severity, number of antipsychotic pills missed, psychiatric symptoms and quality of life during the 24\u2010month treatment period, after controlling for duration of untreated psychosis and treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, roughly 50% (<jats:italic>n<\/jats:italic> = 209) of participants reported recent tobacco, 28% (<jats:italic>n<\/jats:italic> = 113) alcohol and 24% (<jats:italic>n<\/jats:italic> = 95) cannabis use. Tobacco smokers had higher levels of illness severity (<jats:italic>\u03b2<\/jats:italic> = .24; <jats:italic>P<\/jats:italic> &lt; .005), a higher number of missed pills (<jats:italic>\u03b2<\/jats:italic> = 2.89; <jats:italic>P<\/jats:italic> &lt; .05), higher psychiatric symptoms and lower quality of life during treatment relative to non\u2010smokers. Alcohol users had a higher number of missed pills (<jats:italic>\u03b2<\/jats:italic> = 3.16; <jats:italic>P<\/jats:italic> &lt; .05) during treatment and cannabis users had higher levels of illness severity (<jats:italic>\u03b2<\/jats:italic> = .18; <jats:italic>P<\/jats:italic> &lt; .05) and positive symptoms (<jats:italic>\u03b2<\/jats:italic> = 1.56; <jats:italic>P<\/jats:italic> &lt; .05) relative to non\u2010users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tobacco, alcohol and cannabis use are common in youth seeking treatment for FEP. Tobacco smoking was associated with more negative clinical outcomes. These findings have implications for including interventions targeting these areas of substance use within current CSC models.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12542","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:26:36Z","timestamp":1516634796000},"page":"142-146","source":"Crossref","is-referenced-by-count":68,"title":["Impact of tobacco, alcohol and cannabis use on treatment outcomes among patients experiencing first episode psychosis: Data from the national RAISE\u2010ETP study"],"prefix":"10.1111","volume":"13","author":[{"given":"Oladunni","family":"Oluwoye","sequence":"first","affiliation":[{"name":"Initiative for Research and Education to Advance Community Health Washington State University  Spokane Washington"},{"name":"Program of Excellence in Addictions Research Washington State University  Spokane Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Monroe\u2010DeVita","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Sciences University of Washington School of Medicine  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Burduli","sequence":"additional","affiliation":[{"name":"Initiative for Research and Education to Advance Community Health Washington State University  Spokane Washington"},{"name":"Program of Excellence in Addictions Research Washington State University  Spokane Washington"},{"name":"Elson S. Floyd College of Medicine Washington State University  Spokane Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Chwastiak","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Sciences University of Washington School of Medicine  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling","family":"McPherson","sequence":"additional","affiliation":[{"name":"Program of Excellence in Addictions Research Washington State University  Spokane Washington"},{"name":"Department of Psychiatry and Behavioural Sciences University of Washington School of Medicine  Seattle Washington"},{"name":"Elson S. Floyd College of Medicine Washington State University  Spokane Washington"},{"name":"Providence Medical Research Centre Providence Health Care  Spokane Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon M.","family":"McClellan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Sciences University of Washington School of Medicine  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"McDonell","sequence":"additional","affiliation":[{"name":"Initiative for Research and Education to Advance Community Health Washington State University  Spokane Washington"},{"name":"Program of Excellence in Addictions Research Washington State University  Spokane Washington"},{"name":"Elson S. Floyd College of Medicine Washington State University  Spokane Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1192\/apt.bp.105.002006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.106.024448"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu095"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.187.48.s116"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.11.016"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12380"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.07.023"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033339"},{"issue":"338","key":"e_1_2_6_10_1","first-page":"218","article-title":"Clinical global impression scale","volume":"76","author":"Guy W.","year":"1976","journal-title":"The ECDEU Assessment Manual for Psychopharmacology"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/10.3.388"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15050632"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09289"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/13.2.261"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181f058a0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.181.4.321"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16050627"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201400413"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11r07222"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450190043026"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(03)00027-0"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713000883"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.04.004"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.057471"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.017236"}],"container-title":["Early Intervention in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feip.12542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.12542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T05:49:41Z","timestamp":1694670581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eip.12542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/eip.12542"],"URL":"https:\/\/doi.org\/10.1111\/eip.12542","archive":["Portico"],"relation":{},"ISSN":["1751-7885","1751-7893"],"issn-type":[{"value":"1751-7885","type":"print"},{"value":"1751-7893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]}}}