{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T17:10:39Z","timestamp":1781543439079,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Janssen Scientific Affairs, LLC"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This post hoc analysis of a double\u2010blind (DB), randomized, placebo\u2010controlled, relapse\u2010prevention study evaluated the effects of paliperidone palmitate once\u2010every\u20103\u2010months (PP3M) in a subpopulation of adults with early illness schizophrenia (duration \u22645 years) from a clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients received either PP3M or placebo every 3 months in the DB phase. The primary efficacy variable was time from randomization to first relapse. Symptom severity, patient functioning, and safety were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 119 patients who entered the DB phase met the criteria for early illness schizophrenia (PP3M, <jats:italic>n<\/jats:italic>\u2009=\u200962; placebo, <jats:italic>n<\/jats:italic>\u2009=\u200957). PP3M significantly delayed time to relapse vs placebo (<jats:italic>P<\/jats:italic>\u2009=\u2009.035; hazard ratio, 3.08; 95% CI, 1.08\u20108.80). Symptomatic control and patient functioning were maintained in the PP3M group but significantly worsened in the placebo group. There were no unexpected tolerability findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PP3M reduced relapse risk and maintained symptomatic and functional improvements compared with placebo in patients with early illness schizophrenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12685","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T08:49:05Z","timestamp":1530607745000},"page":"667-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Paliperidone palmitate once\u2010every\u20103\u2010months in adults with early illness schizophrenia"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-9578","authenticated-orcid":false,"given":"Karimah S.","family":"Bell Lynum","sequence":"first","affiliation":[{"name":"Janssen Scientific Affairs, LLC  Titusville New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Turkoz","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development, LLC  Titusville New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Kim","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC  Titusville New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v2.i5.74"},{"key":"e_1_2_6_3_1","article-title":"Treatment effect with paliperidone palmitate compared with oral antipsychotics in patients with recent\u2010onset versus more chronic schizophrenia and a history of criminal justice system involvement","volume":"12","author":"Alphs L.","year":"2015","journal-title":"Early Intervention in Psychiatry"},{"issue":"6","key":"e_1_2_6_4_1","first-page":"336","article-title":"Rethinking the role of long\u2010acting atypical antipsychotics in the community setting","volume":"27","author":"Altamura A. 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